Data was sourced from the Metabolomics GWAS server and the FinnGen project.Our research conducted a comprehensive MR analysis across 486 serum metabolites to investigate their causal role in DR. After stringent selection and validation of instrumental variables, we focused on 480 metabolites for ...
Known links between genetic loci and serum metabolites were taken from the GWAS Catalog46 (https://www.ebi.ac.uk/gwas/) and the GWAS server2,22 (http://metabolomics.helmholtz-muenchen.de/gwas/). Code availability Source code for analysis is available at https://github.com/noambar/Serum...
We used existing genomic databases and prior blood metabolomics GWAS to assess the novelty of our locus-metabolite associations. To determine whether mQTLs of known metabolites were novel, we first utilized the PhenoScanner package for R. A 1 MB region around each sentinel SNP associated with a m...
Serum metabolite levels were measured by three different technical platforms (BM, UM, and GM) in 500 healthy Dutch individuals. BM indicates samples measured on the Brainshake Metabolomics/Nightingale Health metabolic platform. These samples were processed following the automated standard protocol provided...
Untargeted metabolomics analysis revealed significantly higher levels of several metabolites, including lactate, in the stools of Lactobacillus-colonized mice, when compared to GF control mice. Moreover, we demonstrate that dietary lactate treatment alone boosted memory in conventional mice. Mechanistically,...
metabolomics and bioinformatics The CD5+ dendritic cell population expanded during the course of ICB therapy, and this expansion was encouraged by low levels of interleukin-6 (IL-6), promoting their independent differentiation. CD5 expression by DCs was crucial for generating effective protective CD5...
Functional genomics assays like gene expression profiling, metabolomics and proteomics are used as input data by different systems-level analysis approaches such as Gene Regulatory Network (GRN) inference, Pathway Analysis (PA) and Flux Balance Analysis (FBA). Functional annotation, a core activity of...
51 Human Metabolome Database (HMDB) Metabolomics databases http://www.hmdb.ca 52 Clinicaltrial.gov Experimental approaches http://clinicaltrials.gov 53 Library of Integrated Network based Cellular Signatures(LINCS) Experimental approaches http://www.lincsproject.org 54 NCGC Database Experimental approach...
a,b, Enrichment of AD genetic risk factor proteins as identified by GWAS in TMT AD network modules (a). The dashed red line indicates aZscore of 1.96 (P = 0.05), above which enrichment was considered significant. Enrichment in M42 is driven by ApoE. Modules are ordered by relatedness...
Given that there are strong genetic effects associated with warfarin dosing requirements, there has also been interest in whether genetic factors may determine outcomes with the DOACs, A GWAS conducted in a subset of patients from the RE-LY trial reported genome-wide SNP associations for both peak...