ObjectiveTo provide a quantitative map of relationships between metabolic traits, genome-wide association studies (GWAS) variants, metabolic syndrome (MetS), and metabolic diseases through factor analysis and structural equation modeling (SEM).Design and MethodsCross-sectional data were collected on 1,300...
There are, however, no studies to date examining the genetic associations of ABSI and HI, no allometric counterpart of WHR and no insight into the influence of the correlation of traditional body-shape indices with height. The aims of our study, therefore, were to perform the first GWAS of ...
Genome-wide screen for metabolic syndrome susceptibility loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits. Circ Cardiovasc Genet. 2012;5:242–9. Article PubMed PubMed Central Google Scholar Hollingworth P, Sweet R, Sims...
Modeling metabolic syn- drome through structural equations of metabolic traits, comorbid diseases, and GWAS variants. Obe- sity (Silver Spring). 2013; 21(12):E745-54.Modeling metabolic syndrome through structural equations of metabolic traits,comorbid diseases,and GWAS variants. Karns R,Succop P,...
in the SDHB(succinate dehydrogenase type B) in patients with paraganglioma syndrome shows elevated risk to develop multiple types of RCC.GWAS in almost 6000 RCC cases demonstrated that loci on 2p21 and 11q13.3 play a role in RCC. Although EPAS1 gene encoding a transcription factor operative in...
Water-pipe smoking and metabolic syndrome: a population-based study. PLoS One. 2012;7:e39734. Article CAS PubMed PubMed Central Google Scholar Shahid SU, Shabana NA, Rehman A. Association patterns of endothelial nitric oxide synthase gene (NOS3) variant Glu298Asp with blood pressure and ...
48 There are several sources of evidence that variation at this locus is associated with neurobehavioral phenotypes. For example, the 17q21.31 microdeletion syndrome is associated with the H2 haplotype, which carries additional low-copy repeats susceptible to non-allelic homologous recombination. The ...
Heritability and Genetic Correlations Explained by Common SNPs for Metabolic Syndrome Traits. PLoS Genet 8, e1002637 (2012). 23. Schizophrenia Working Group of the Psychiatric Genomics Consortium. Biological insights from 108 schizophrenia-associated genetic loci. Nature 511, 421–427...
Heritability and Genetic Correlations Explained by Common SNPs for Metabolic Syndrome Traits. PLoS Genet 8, e1002637 (2012). 23. Schizophrenia Working Group of the Psychiatric Genomics Consortium. Biological insights from 108 schizophrenia-associated genetic loci. Nature 511, 421–427 (2014). 24. ...
In the present study, we investigate the power of including endophenotypes in the analyses instead of increasing sample size. Furthermore, we use the pig, which is an established model for the highly prevalent human diseases involving lipid metabolism (metabolic syndrome, diabetes, obesity, and card...