Male-pattern baldness (MPB) is a common and highly heritable trait characterized by androgen-dependent, progressive hair loss from the scalp. Here, we carry out the largest GWAS meta-analysis of MPB to date, comprising 10,846 early-onset cases and 11,672 controls from eight independent cohorts...
GWAS meta-analysis The European Alzheimer & Dementia Biobank (EADB) consortium brings together the various European GWAS consortia already working on AD. A new dataset of 20,464 clinically diagnosed AD cases and 22,244 controls has been collated from 15 European countries. The EADB GWAS results...
The Preterm Genome Project, which is sponsored by WHO, is the largest GWAS project that is currently underway aiming to examine genetic variation and PTB.(7) This project plans in future to analyze the impact of other environmental factors with this relationship, including maternal conditions such...
Meta-Analysis of GWAS for Handedness: Results from the ENGAGE consortiumMedland, S.ELindgren, C.MMagi, RNeale, B.MAlbrecht, EEsko, TEvans, D.MHottenga, J.JIkram, M.AMangino, M
We focused on the 20 well-established AD risk genes identified and validated in the largest AD GWASs to date.10-15 In addition to the variants reported in these articles, we included all other variants that were previously associated with brain amyloidosis16-19 (eTable 1 in the Supplement),...
Interestingly, the most significant locus identified in this study (8p22-p21.1) includes the CLU gene, (the top hit from the largest GWAS performed in AD, as discussed below in this review) and previously reported loci by different studies (as 9p, 9q, 10q, and 12p) were not identified...
To evaluate how well cell types clustered, we first found 10% of genes showing the largest variation among cell types, as judged by analysis of variance. Performing hierarchical clustering using dissimilarity of expression for these genes revealed commonalities about the common types of cells (hclust...
Of note, the largest today GWAS meta-analysis of ulcerative colitis (UC), another form of IBD, has shown that, among the 99 confirmed IBD loci meeting genome-wide significance (P < 5 × 10- 8) in UC and/or CD, 28 loci shared association signals between UC and CD, with many common...
et al. A meta-analysis of genome-wide association studies identifies novel longevity genes. Nat. Commun. 10, 3669 (2019). This is the largest GWAS directly studying long-lived participants (aged ≥90 years) compared with shorter-lived (<65) controls to date. Article PubMed PubMed Central ...
As sample sizes grow ever larger with a corresponding increase in the number of unique G–T associations, some expect17 the value of GWAS genetic findings to become less useful for the purpose of drug target selection. We explored this in several ways. We investigated the year that genetic su...