We showed that inflammatory cells carrying the marker of recently migrated cells, the Gr-1 antigen, including polymorphonuclear and mononuclear cells, migrate rapidly into the site of promastigote infection and, subsequently, into draining lymph nodes. Treatment with RB6-8C5 monoclonal antibody reduced...
Cells developed under both conditions expressed the mye- loid marker CD11b. In contrast to 80–90% of the cells generated in the presence of GM-CSF being conventional CD11c + DCs, simultaneous stimulation with LPS reduced CD11c+ cells to < 5% (Supplementary Figure S2 online). The lung CD...
TAMs and MDSCs are all subpopulations of the total tumor infiltrating CD11b+ myeloid cells and they could be distinguished from each other by their specific surface marker profile14. Therefore, Gr-1+CD11b+ myeloid cells, which were also of bone marrow origin, were believed to promote tumor ne...
A protein marker of the onset of growth in germinating wheat, later shown to be associated with the cell wall and more recently to be an oxalate oxidase (EC 1.2.3.4, 224aa). Produces developmental and stress-related release of hydrogen peroxide in the apoplast. See germin like proteins. ger...
Interestingly, GRK2 interacts with Patched1 and inhibits cyclin B1–Patched 1 interaction, allowing for cyclin B1 nuclear accumulation and G2/M transition, whereas GRK2 knockdown in cells and zebrafish results in cell cycle arrest in G2/M stage with accumulation of the mitotic marker pH3 ...
The anti-apoptotic Bcl-2 family protein A1/Bfl-1 regulates neutrophil survival and homeostasis and is controlled via PI3K and JAK/STAT signaling. Cell Death Dis 2016; 7: e2103. Article CAS Google Scholar Zhang F, Liu B, Wang Z, Yu XJ, Ni QX, Yang WT et al. A novel regulatory ...
41. Vroon A. GRK6 deficiency is associated with enhanced CXCR4-mediated neutrophil chemotaxis in vitro and impaired responsiveness to G-CSF in vivo. J Leukoc Biol 2004; 75: 698–704. 42. Gainetdinov RR, Bohn LM, Sotnikova TD, Cyr M, Laakso A, Macrae AD et al. Dopaminergic super...
Targeted disruption of GRK2 in Raw264.7 cells (RAW) through GRK2 siRNA or CRISPR/Cas9 downregulated M1 marker expression and upregulated M2 marker expression and EP4 membrane localization. The downregulated M1/M2 ratio were also shown in macrophages of GRK2+/− mice, as well as upregulated ...
It was shown that GRK2 and GRK5 play a notable role in the pathogenesis of human sepsis by regulating neutrophil chemotaxis, and modulate the outcomes of septic shock via the NF-κB1p105-TPL2-MEK-ERK pathway [61,76,77,78,79]. However, these GRKs have no role in immune cell ...
Neutrophil autoantibodies: a genetic marker in primary sclerosing cholangitis: ulcerative colitis: Siebold F, Slametschka D, Gregor M, Weber P. Gastroenterology 1994;107:532–536Publication » Neutrophil autoantibodies: a genetic marker in primary sclerosing cholangitis: ulcerative colitis: Siebold F,...