Depletion of GR-1-Positive Cells Is Associated with Reduced Neutrophil Inflammation and Astrocyte Reactivity after Experimental Intracerebral Hemorrhage[J] . Matthew Loftspring,Holly Johnson,Aaron Johnson,Joseph Clark.Translational Stroke Research . 2012 (1)...
Thus, ZBP1-mediated IL-1α production is the key initial step of IAV-infected NETs, regulating the duality of the consequent lung inflammation. 展开 关键词: IL-1 ZBP1 influenza virus innate immunity neutrophil DOI: 10.1093/intimm/dxz070 年份: 2020 ...
Neutrophil depletion with Gr-1 mAb elicits emergency granulopoiesis with minimal inflammation.Derek W. CainPilar B. SnowdenGregory D. SempowskiGarnett Kelsoe
We found that the depletion of neutrophils by anti-Gr-1 antibody dramatically delayed wound healing in aged mice. The depletion of neutrophils in young mice had less effect on the kinetics of wound healing. Intravenous G-CSF injection increased the migration of neutrophils to the wound site. ...
The outcome of mice that were depleted of neutrophils using an anti-Gr-1 antibody was compared to that in mice with intact neutrophil count. The effect of neutrophil depletion on blood-brain barrier function was assessed by Evan's blue dye extravasation, and analysis of brain water content was...
Finally, it was demonstrated that ITGB2 mediates these effects mainly through its interaction with intercellular adhesion molecule-1 (ICAM 1) of endotheliocyte. These findings collectively illuminate ITGB2 as a crucial molecular switch that governs the adverse effects of neutrophils post-TBI and could...
These neutrophil genes encompassed functions of apoptosis (A1 and Fas), tissue remodeling (MMP-9), vascular margination ( l-selectin), bacterial killing (BPI), and wound healing (betaglycan), as well as responsiveness of the cells to stress-induced increases in glucocorticoid hormones (GR伪)....
In response to inflammatory stimulation, circulating neutrophils undergo a series of dynamic and metabolic changes characterized by 尾2-intergrin mediated adhesion to microvascular endothelium and subsequent transendothelial migration. During this process, neutrophils release granular contents containing digestive...
Aravindan GR , Pineau C. , Bardin CW , Cheng CY . Ability of trypsin in mimicking germ cell factors that affect Sertoli cell secretory function . J Cell Physiol . 1996 ; 168 : 123 – 133 .Hunt, RC, Hunt, DM, Gaur, N, Smith, A (1996) Hemopexin in the human retina: protection ...
Compared to human bronchial epithelial cell line (16HBE cells), the ratio of p-GR S226 to p-GR S211 (p-GR S226/S211) was significantly higher in ILC3s at baseline and after dexamethasone treatment. In addition, IL-1 beta could induce Ser226 phosphorylation and had a crosstalk effect to...