granule possessed signals targeting them for a particular population of granules, cDNA encoding the secondary granule protein neutrophil gelatinase- associated lipocalin (NGAL) was transfected into HL-60 cells, a cultured human leukemia cell line devoid of secondary granules or secondary granule proteins....
(NE). A serine protease stored in the neutrophil intracellular granules. Circulating tumour cells (CTCs). Cancer cells that have detached from a primary tumour and are found in the bloodstream. Pre-metastatic niche An environment in a secondary organ that provides favourable conditions for the seed...
These findings suggest that even though DMSO-differentiated PLB-985 cells did not possess the same granules as human neutrophils, the “NETosis” capabilities of these differentiated cells are similar to that of human neutrophils. Our data altogether show that PLB-985 cells are different from ...
Neutrophil:A type of white blood cell, a granulocyte that is filled with microscopic granules, little sacs containing enzymes that digest microorganisms. Also known aspolymorphonuclear leukocyteor poly.
(2018). Armed for destruction: formation, function and trafficking of neutrophil granules. Cell Tissue Res. 371, 455-471. doi: 10.1007/ s00441-017-2731-8Yin C, Heit B (2018) Armed for destruction: formation, function and trafficking of neutrophil granules. Cell Tissue Res. https://doi....
Lipocalin 2 (Lcn2) is a 25-kDa glycoprotein that has initially been extracted from neutrophil granules. Expression of Lcn2 is induced under various pathophysiological conditions. It is also known as an early marker of kidney and heart injury. High-level expression of recombinant Lcn2 neutrophil ...
Human granulocytes are classically characterized by their capacity to act as phagocytes, degranulators secreting preformed lytic enzymes from their granules, and produce reactive oxygen species (ROS) to destroy bacteria, parasites, and fungi. Basophils and eosinophils are mainly involved in the defense...
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Neutrophil granules and secretory vesicles in inflammation The neutrophil is a major effector cell of innate immunity. Exocytosis of granules and secretory vesicles plays a pivotal role in most neutrophil functions... M Faurschou,N Borregaard - 《Microbes & Infection》...
Functional analysis of infection-induced neutrophils was further performed based on transcriptome analysis of various enzymes (Fig.4c). Here, 14 dpi preNeu N1 cells show occasional high expression ofMpoandElane. Both genes encode azurophilic granules enzymes, with MPO being an NADPH oxidase-linked en...