We conclude that this panel of genes is selective for predicting a response to TNFi and is not a surrogate marker for disease improvement. We also show that in RA, there is great plasticity in neutrophil phenot
metastasis and that interventions targeting the “HMGB1-CD62Ldimneutrophil-NETs” axis could inhibit lung metastasis. Our results suggest that the combination of HMGB1 and CD62Ldimneutrophils is a potential marker for breast cancer lung metastasis and is novel target for future prevention and therapy...
classified as anti-tumor (N1) and pro-tumor (N2) phenotypes [90]. The pro-tumor mechanisms of neutrophils include promoting neovascularization, releasing neutrophil extracellular traps to enhance tumor cell proliferation, inducing extracellular matrix remodeling and immunosuppressive effects ...
Despite functional differences, no definitive surface marker has been identified to distinguish N1 and N2 tumor-associated neutrophils (TANs),26 indicating these subpopulations may represent neutrophils with differential activation states. Overall, these results indicate that neutrophil polarization is likely ...
NETs, neutrophil extracellular traps; NETRGs, neutrophil extracellular traps-related genes; CDF, Cumulative Distribution Function; HCC, hepatocellular carcinoma; TCGA, The Cancer Genome Atlas; PCA, Principal Component Analysis. 3.3. Biological behaviors and immune infiltration characteristics among the three...
their unregulated release can aggravate tissue damage and could be detrimental to the host. Several constituents of neutrophil granules have also been associated with various inflammatory diseases including cancer. In cancer setting, their excessive release may modulate tissue microenvironment which ultimately...
Given that the clinical outcomes of patients with GC remains poor and that few prognostic factors currently exist for this disease following surgery [38], intratumoral neutrophil cell frequency might prove to be a useful clinical marker in the future. Moreover, neutrophils may influence tumor ...
4A). The knockout efficiency of Yap1 in the marker-verified primary stromal cells from Yap1 cKO mice was confirmed by genotyping (data not shown) and Western blot analysis (Figs. 4B and C). As expected, qPCR analysis showed that GROα was drastically upregulated in primary stromal cells ...
The corrected PC matrixes were used to perform unsupervised shared-nearest neighbor–based clustering and UMAP visualization analysis. Differential expression analysis based on clusters was used to identify marker genes and manually annotate clusters based on information from literature....
[171]. By promoting EMT in breast cancer, overexpression of SNAIL could cause the resistance of breast cancer cells to the lysis induced by CD8+T cells [178]. Additionally, negative regulation of mitochondrial function induced by HIF-1α by promoting the activity of PDK has made this factor ...