h Heatmap showing the differential metabolites in neutrophils between the sham and TBI groups in mice. Higher expression levels are indicated by red and lower by green. i Bubble chart showing the pathway activities through the differential metabolites of neutrophils from mice (sham group vs. TBI ...
MUC16 (CA125) is a commonly used tumor marker for ovarian cancer screening and reported to be an immunosuppressive factor by acting on the sialic acid-binding immunoglobulin-like lectin-9 (Siglec-9) on the surface of natural killer cells (NK cells), B ce
Patients with a high NLR had a significantly higher average number of CD15+TANs in the primary tumors, compared to patients with a low NLR (Fig. 6d). Fig. 5 a, b The scatter chart of CD15+TANs and pre-operative Neutrophil-to-Lymphocyte Ratio (NLR). a: In primary tumor, Positive ...
which mediated neutrophil N2 polarization and miR-4745-5p/3911 upregulation. We further employed ddPCR (droplet digital PCR) to detect the expression of miR-4745-5p/3911 in N2 TANs exosomes from human serum samples and found their increased levels in gastric cancer patients compared...
Serum interleukin-8 (IL-8) levels and tumor neutrophil infiltration are associated with worse prognosis in advanced cancers. Here, using a large-scale retrospective analysis, we show that elevated baseline serum IL-8 levels are associated with poor outco