Recently, we demonstrated that the down-regulation or inhibition of glycogen synthase kinase 3 (GSK-3) down-regulates PD-1 expression in infectious diseases and cancer (Taylor et al., 2016 Immunity 44, 274-86; 2018 Cancer Research 78, 706-717; Krueger and Rudd 2018 Immunity 46, 529-531)...
2.6.2.1. Glycogen synthase regulation The regulatory mechanisms that modulate the activity of glycogen synthase in humans differ partially in liver and muscle, as these two glycogen depots carry out different functions. Reversible phosphorylation and dephosphorylation of glycogen synthase is a major determi...
Paul JR, DeWoskin D, McMeekin LJ, Cowell RM, Forger DB, Gamble KL (2016) Regulation of persistent sodium currents by glycogen synthase kinase 3 encodes daily rhythms of neuronal excitability. Nat Commun 7:13470. CrossRefPaul, J. R. et al. Regulation of persistent sodium currents by ...
The dephosphorylation of S2P-labeled glycogen synthase was studied using a phosphoprotein phosphatase purified l,OOO-fold from rabbit skeletal muscle by DEAE-cellulose column chromatography and Sephadex G-200 chromatography. The phosphatase activity, which was stimulated by MnCl, (1 to 10 mM) but not...
In vivo regulation of glycogen synthase kinase-3beta (GSK3beta) by serotonergic activity in mouse brain. The goal of this study was to determine if serotonergic activity, which is impaired in depression, regulates the phosphorylation of glycogen synthase kinas... X Li,W Zhu,MS Roh,... - 《...
Regulation of the Caenorhabditis elegansoxidative stress defense protein SKN-1by glycogen synthase kinase-3Jae Hyung An* † , Kelly Vranas*, Michael Lucke*, Hideki Inoue ‡ , Naoki Hisamoto ‡ , Kunihiro Matsumoto ‡ ,and T. Keith Blackwell* §¶*Section on Developmental and Stem Cell ...
In vivo regulation of glycogen synthase kinase 3β activity in neurons and brains. Sci. Rep. 7:8602. doi: 10.1038/s41598-017-09239-5Krishnankutty, A.; Kimura, T.; Saito, T.; Aoyagi, K.; Asada, A.; Takahashi, S.I.; Ando, K.; Ohara-Imaizumi, M.; Ishiguro, K.; Hisanaga, S...
R. (2001), ChemInform Abstract: Glycogen Synthase Kinase-3: Properties, Functions, and Regulation. ChemInform, 32: no. doi: 10.1002/chin.200141285 Author Information Div. Exp. Ther., Ont. Cancer Inst., Ottawa, Ont. M5G 2M9, Can. Publication History Issue published online: 24 MAY 2010 ...
Regulation of glycogen synthase: A relation of enzymic properties with biological function Identification of residues involved in regulation by the allosteric ligand glucose-6-P and by phosphorylation. J Biol Chem 275, 27753-61. :Roach, P. J., Larner, J.: Regulation of glycogen synthase: A re...
Intracellular regulation of oocyte meiosis is not completely understood. However, reversible phosphorylation, which involves serine/threonine protein kinases and phosphatases (PP), is an important mediator. Glycogen synthase kinase-3 (GSK-3) is a highly conserved serine/threonine protein kinase. Currently...