Regulation of glycogen synthesis in the liver. Am J Med 1988;85:77-85Nuttall FQ, Gilboe DP, Gannon MC, Niewoehner CB, Tan AW. Regulation of glycogen synthesis in the liver. Am. J. Med. 1988; 85 :77–85. [ PubMed ]Nuttall, FQ, Gilboe, DP, Gannon, MC, Niewoehner, CB, Tan, ...
Integration of the regulation of glycogen synthesis and breakdown Glucagon Epinephrine Receptors Adenylyl Cyclase Obviously, insulin has a role in this metabolism. See next slides. cAMP ATP AMP Phosphodiesterase R2C2 R2(cAMP)4 Ca2+ 2C ACTIVE PKA Glycogen synthase Phosphorylase b Kinase Glycogen Phospho...
Regulation of glycogen synthesis and degradation With glucose-1-phosphate as the initial substrate, glycogen synthesis consumes 1 mol of ATP per mole of glucose incorporated into glycogen. ATP is needed to regenerate UTP that is produced from UDP during glycogen synthesis. Glycogenolysis produces gluco...
(9, 10, 27, 29) support the possibility that at birth hormonal regulation of glycogen metabolism is competent, but direct glucose regulation of glycogen synthesis has not developed. In humans, development of rapid glucose and glycogen mobiliz- ing responses precedes birth (1, 13, 26), and ...
Streptomyces are our principal source of antibiotics, which they generate concomitant with a complex developmental transition from vegetative hyphae to spores. c-di-GMP acts as a linchpin in this transition by binding and regulating the key developmental
glycogensynthesis)whenglucoseisabundant(activityismodulatedbyfructosephosphatesandaregulatoryprotein)3 RegulationofPFK-1 ☺ATPisasubstrateandanallostericinhibitorofPFK-1 ☺AMPallostericallyactivatesPFK-1byrelievingtheATPinhibition(ADPisalsoanactivatorinmammaliansystems)☺ChangesinAMPandADPconcentrationscancontrolthe...
However, the genes that were associated with hypomethylated CpG sites in the fetal samples were strongly enriched for pathways of insulin receptor signaling, regulation of glycogen synthase activity, differentiation processes, and developmental functions (Table 1B)....
S.mutans has two genes (glgC and glgD) respectively encoding putative ADP-glucose pyrophosphorylases (ADP-Glc PPase), a key enzyme for glycogen synthesis in most bacteria. Herein, we report the molecular cloning and recombinant expression of both genes (separately or together) followed by the ...
glycogen synthase [126,127]. (iii) Axin dephosphorylation. As a scaffold protein that directly interacts with other core components of the destruction complex [12,129], the scaffolding function of Axin is essential in the process of β-catenin phosphorylation by GSK3 because the interaction of ...
Glycogen synthase kinase 3β (GSK-3β) could phosphorylate Thr-328 of PKM2, and phosphorylation of the PKM2 Thr-328 site is essential for maintaining PKM2 stability and regulating biological functions of glycolysis, mitochondrial respiration, proliferation and apoptosis. HSP90 also has a function to...