The major yeast glycogen synthase, Gsy2p, is inactivated by phosphorylation and activated by the allosteric ligand glucose-6-P. From studies of recombinant proteins, the control can be accommodated by a three-state model, in which unphosphorylated enzyme has intermediate activity (state II). ...
(2003) Apolipoprotein E and beta-amyloid (1-42) regulation of glycogen synthase kinase-3beta. Journal of Neurochemistry, 87, 1152-1164.Cedazo-Minguez, A.; Popescu, B.O.; Blanco-Millan, J.M.; Akterin, S.; Pei, J.J.; Winblad, B.; Cowburn, R.F. Apolipoprotein E and beta-...
Since the activation of each signaling pathway results in a decrease in GSK3β activity, we examined the specificity of their downstream effects in the same cell type. Insulin induces an increased activity of glycogen synthase but has no influence on the protein level of β-catenin. In contrast...
This involves inhibition of glycogen synthase kinase (GSK)-3β, a kinase whose dysregulation is linked to both metabolic and neurological disorders56. GSK-3β phosphorylation of dynein reduces its interaction with NudEL55. CDK5 can inhibit GSK-3β, but to our knowledge the opposite has not yet...
A. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 378, 785–789 (1995). Article CAS PubMed Google Scholar Craxton, A., Jiang, A., Kurosaki, T. & Clark, E. A. Syk and Bruton's tyrosine kinase are required for B-cell antigen receptor-...
R. (2001), ChemInform Abstract: Glycogen Synthase Kinase-3: Properties, Functions, and Regulation. ChemInform, 32: no. doi: 10.1002/chin.200141285 Author Information Div. Exp. Ther., Ont. Cancer Inst., Ottawa, Ont. M5G 2M9, Can. Publication History Issue published online: 24 MAY 2010 ...
glycogen synthase [126,127]. (iii) Axin dephosphorylation. As a scaffold protein that directly interacts with other core components of the destruction complex [12,129], the scaffolding function of Axin is essential in the process of β-catenin phosphorylation by GSK3 because the interaction of ...
Glycogen synthase kinase 3β (GSK-3β) could phosphorylate Thr-328 of PKM2, and phosphorylation of the PKM2 Thr-328 site is essential for maintaining PKM2 stability and regulating biological functions of glycolysis, mitochondrial respiration, proliferation and apoptosis. HSP90 also has a function to...
“primed” glycogenin is performed by the concerted action of glycogen synthase (GS) and branching enzyme. Glycogen synthase elongates the glycogen chain whereas branching enzyme produces new branches, creating a mature glycogen granule. In contrast to glycogen synthesis, glycogenolysis is a process ...
This invention relates generally to a method of treating inflammation and associated diseases and disorders by administering an agent that inhibits glycogen synthase kinase 3 activi