We have already heard about the many advances that have been made in our understanding of the subunit structure, mechanism of action, functional sites and regulation of the cAMP-dependent protein kinase, of pho
H2S is involved in many biological functions, including interactions with nitric oxide, activation of molecular signalling cascades, post-translational modifications and redox regulation. Various preclinical and clinical studies have shown that H2S and its synthesizing enzymes — cystathionine γ-lyase, ...
Pyruvate kinase (PK), as one of the key enzymes for glycolysis, can encode four different subtypes from two groups of genes, although the M2 subtype PKM2 is expressed mainly during embryonic development in normal humans, and is closely related to tissue repair and regeneration, with the deepenin...
Regulation of ferroptotic cancer cell death by GPX4. Cell. 2014;156:317–31. PubMed Central CAS Google Scholar Dixon SJ, Patel DN, Welsch M, Skouta R, Lee ED, Hayano M, et al. Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis. ...
2. Biosynthesis and elongation of mammalian N-linked glycans 3. Role of N-glycans in protein folding, stability, and quality control in the ER 4. Regulation of mammalian N-glycosylation 5. N-glycosylation in cell biology, signal transduction, and immunity 6. Immunotherapy, glycoediting and drug...
This complex structure is synthesized by the coordinate activities of the starch synthases (SS), which elongate the polysaccharide chain by addition of glucose units via α-1,4 linkages using ADP- glucose as a donor, and branching enzymes (BE), which branch the polysaccharide chain by cleavage ...
Next, we discuss the regulation of the intracellular concentration of cyclic nucleotides via phosphodiesterases, the enzymes that degrade cAMP and/or cGMP, and via A-kinase-anchoring proteins that refine signal compartmentalization of cAMP signaling. We also provide an overview of the available data ...
Bailey PJ, Dougherty HW, Mandel L, Reese AC, Landau BR: Distribution of enzymes of glycogen metabolism and calcium uptake in skeletal muscle. Arch Biochem Biophys (161): 592–600, 1974. CrossRef Haugaard ES, Haugaard N: The action of insulin on glycogen synthesis in rat diaphragm from int...
Upregulation of Pparγ and Srebp1-mediated de novo lipogenesis has been associated with inflammation, increased proliferation and tumour progression in many types of cancer and thus provides a possible link between HFHSD-induced metabolic signalling, crypt-cell hyperproliferation and increased risk of ...
enzymes to place the transgenes under the control of the UAS promoter.UAS-mnb-WTandUAS-mnb-D401tertransgenic flies were obtained by P-element-mediated germline transformation29. To analyse the eye phenotype, newly eclosed flies were collected and allowed to mate for 2–3 days. Wings from ...