(2013) Regulation of glycogen synthase from mammalian skeletal muscle--a unifying view of allosteric and covalent regulation. FEBS J. 280, 2-27 doi:10.1111/febs.12059Palm DC, Rohwer JM, Hofmeyr JH. Regulation of glycogen synthase from mammalian skeletal muscle--a unifying view of allosteric ...
GlgX, GlgX-c-di-GMP complex and the GlgX-c-di-GMP complex with substrate acarbose (Figs.4,5, and7). TheS. venezuelaeGlgX-c-di-GMP structure revealed that binding the second messenger stabilizes the active enzyme conformation, thus explaining how it acts as an allosteric regulator (Fig....
The major yeast glycogen synthase, Gsy2p, is inactivated by phosphorylation and activated by the allosteric ligand glucose-6-P. From studies of recombinant proteins, the control can be accommodated by a three-state model, in which unphosphorylated enzyme has intermediate activity (state II). Glucos...
Previous studies indicated that allosteric regulation of bacterial glycogen synthesis occurs at the level of ADP-glucose synthase (reviewed by Preiss, J. (1969) in Current Topics in Cellular Regulation (Horecker, B. L., and Stadtman, E. R., eds) Vol. 1, pp. 125–160, Academic Press, ...
An insulin stimulated kinase, PKB or AKT, inhibits GSK-3 and helps maintain glycogen synthase active. G-6-P acts as a positive allosteric effector of the normally inactive phosphorylated form of the enzyme. Moreover, glycogen, the final product of the pathway, exerts direct inhibitory action ...
responds to hormonal control and second messenger signals. One of the primary forms of control is the varied phosphorylation of glycogen synthase and glycogen phosphorylase. Enzymes under hormonal control regulate phosphorylation, and there are many different effectors compared to allosteric regulation ...
Glycogen synthase activity is a key component in the regulation of glycogen resynthesis. Glycogen synthase enzyme exists in 2 states: the less active, more phosphorylated (D) form which is under allosteric control of glucose-6-phosphate, and the more active, less phosphorylated (I) form which is...
(for reviews see Bollen et al.1998; Brown2004). In general, activation of glycogen synthesis results in the inhibition of the degradative pathway, and vice versa. Glycogen synthase and GP represent two central elements of this regulation. Glycogen synthase is tightly controlled by the reversible ...
Phospho-Glycogen synthase 1(Ser641)Rabbit Monoclonal Antibody(磷酸糖原合成酶1(SER641)兔单克隆抗体)是用磷酸糖原合成酶1对兔进行系统免疫然后筛选出兔磷酸糖原合成酶1致敏B细胞后与骨髓肿瘤细胞杂交最后制得既能产生单一抗体,又能无限增殖的杂种细胞系。磷酸糖原合成酶1是一个在糖原生成中关键的酶,可以转化葡萄糖...
Glycogen synthase kinase-3 (GSK-3) is a protein serine kinase implicated in the cellular response to insulin. The enzyme is the mammalian homologue of the ... K Hughes,E Nikolakaki,SE Plyte,... - 《Embo Journal》 被引量: 1088发表: 1993年 Adiponectin modulates the glycogen synthase kinase...