PROBLEM TO BE SOLVED: To provide a method for modulating survival of endothelial cells, migration thereof, and blood vessel formation, to provide a composition therefor, to provide a glycogen synthase kinase 3 (GSK 3) molecule, to provide an agent for modifying kinase activity of the molecule,...
Glycogen synthase kinase (GSK) 3beta is a negative regulator of stress-induced cardiomyocyte hypertrophy. It is not clear, however, if GSK-3beta plays any role in regulating normal cardiac growth and cardiac function. Herein we report that a transgenic mouse expressing wild type GSK-3beta in ...
Pyruvate kinase (PK), as one of the key enzymes for glycolysis, can encode four different subtypes from two groups of genes, although the M2 subtype PKM2 is expressed mainly during embryonic development in normal humans, and is closely related to tissue repair and regeneration, with the deepenin...
A. Glycogen-dependent effects of AICA riboside on AMP-activated protein kinase and glycogen synthase activities in rat skeletal muscle. Diabetes 51, 284–292 (2002). Article CAS PubMed Google Scholar Watt, M. J. et al. β-Adrenergic stimulation of skeletal muscle HSL can be overridden by ...
Function and evolution of ‘green’ GSK3/Shaggy-like kinasesdoi:10.1016/j.tplants.2011.10.002Glycogen synthase kinase 3 (GSK3) proteins, also known as SHAGGY-like kinases, have many important cell signalling roles in animals, fungi and amoebae. In particular, GSK3s participate in key ...
et al. Activation of glycogen synthase kinase-3 inhibits long-term potentiation with synapse-associated impairments. J. Neurosci. Off. J. Soc. Neurosci. 27, 12211–12220. https://doi.org/10.1523/JNEUROSCI.3321-07.2007 (2007). Article CAS Google Scholar Peineau, S. et al. The role of ...
Glycogen synthase kinase 3 (GSK-3) has previously been shown to play an important role in the regulation of apoptosis. However, the nature of GSK-3 effector pathways that are relevant to neuroprotection remains poorly defined. Here, we have compared neuroprotection resulting from modulation of GSK...
To determine whether FANCL regulates the function of nuclear β-catenin, 293FT cells stably expressing a LEF-TCF-eGFP reporter were transfected with either vector-control, LacZ, or FANCL and treated with BIO [(2′Z,3′E)-6-bromoindirubin-3′-oxime] a potent glycogen synthase kinase-3 (GSK...
In addition, we have determined the first structure of glycogen synthase in its "closed", catalytically active conformation bound to ADP-glucose. We also determined the structure of glycogen synthase bound to malto-oligosaccharides, showing for the first time that an enzyme in the starch ...
Several kinases, including casein kinase 1 (CK1) and glycogen-synthase kinase 3 (GSK3), are also involved in the regulation of NFAT nuclear import and export. In activated T cells, NFAT proteins synergize with activator protein 1 (AP1) transcription factors at composite sites that are located ...