PROBLEM TO BE SOLVED: To provide a method for modulating survival of endothelial cells, migration thereof, and blood vessel formation, to provide a composition therefor, to provide a glycogen synthase kinase 3 (GSK 3) molecule, to provide an agent for modifying kinase activity of the molecule,...
Protein phosphatase 1 (PP1) is one of the major protein phosphatases in eukaryotic cells. It plays a key role in regulating glycogen synthesis, by dephosphorylating crucial enzymes involved in glycogen homeostasis such as glycogen synthase (GS) and glycogen phosphorylase (GP). To play this role,...
glycogen synthase 1 (GYS1) chemokine (C-X-C motif) ligand 14 (CXCL14) non-small cell lung cancer (NSCLC) overall survival (OS) Glioblastoma (GBM) glioblastoma stem cell (GSC) Gastric cancer (GC) Tissue Microarray-Immunohistochemistry (TMA-IHC) AMP-activated protein kinase (AMPK) Colorectal...
As glycogen synthase kinase 3β (Gsk3β) is a negative regulator of Wnt/β-catenin signalling and an important modulator of cellular metabolism, we checked Gsk3β activity39. Decreased levels of phosphorylated Gsk3β in HFHSD-derived SI crypts indicated increased Gsk3β activity and enhanced ...
During metabolism, mTORC2 rapidly activates AKT, which inhibits glycogen synthase 3β (GSK3β) at the mitochondrial-endoplasmic reticulum (ER) junction. The recruitment of hexokinase I (HK-I) to the voltage-dependent anion channel (VDAC) on mitochondria promotes respiration by promoting metabolite ...
Beyond the brain: disrupted in schizophrenia 1 regulates pancreatic β-cell function via glycogen synthase kinase-3β.insulinsecretiondiabetesT2DIndividuals with schizophrenia and their first-degree relatives have higher rates of type 2 diabetes (T2D) than the general population (18-30 vs. 1.2-6.3%)...
Glycogen synthase kinase 3β (GSK-3β) could phosphorylate Thr-328 of PKM2, and phosphorylation of the PKM2 Thr-328 site is essential for maintaining PKM2 stability and regulating biological functions of glycolysis, mitochondrial respiration, proliferation and apoptosis. HSP90 also has a function to...
Function and evolution of 'green' GSK3/Shaggy-like kinases. Glycogen synthase kinase 3 (GSK3) proteins, also known as SHAGGY-like kinases, have many important cell signalling roles in animals, fungi and amoebae. In ... Y Saidi,TJ Hearn,JC Coates - 《Trends in Plant Science》 被引量: ...
Glycogen synthase kinase 3 (GSK-3) has previously been shown to play an important role in the regulation of apoptosis. However, the nature of GSK-3 effector pathways that are relevant to neuroprotection remains poorly defined. Here, we have compared neuroprotection resulting from modulation of GSK...
In comparison, a selective IMPase inhibitor (L-690,330) attenuated the behavioural response to DOI whereas glycogen synthase kinase inhibitor (AR-A014418) did not. Finally, ebselen increased regional brain 5-HT synthesis and enhanced the increase in extracellular 5-HT induced by citalopram. ...