Further disclosed are methods of identifying a putative substrate-competitive peptide inhibitor of GSK-3 which are effected by computational modeling and screening.Hagit Eldar-FinkelmanMiriam EisensteinAvital Licht-Murava
Beurel E;Blivet-Van Eggelpoel M J;Kornprobst M;.Glycogen synthase kinase-3 inhibitors augment TRAIL-induced apoptotic death in human hepatoma cells.Biochemical Pharmacology.2009.54-65Beurel E, Blivet-Van Eggelpoel MJ, Kornprobst M, et al. Glycogen synthase kinase-3 inhibitors augment TRAIL-...
Molecular Biomedicine (2022) 3:43 https://doi.org/10.1186/s43556-022-00111-1 Molecular Biomedicine RESEARCH Open Access Inhibition of glycogen synthase kinase‑3‑beta (GSK3β) blocks nucleocapsid phosphorylation and SARS‑CoV‑2 replication Tirosh Shapira1,2 , Selvarani ...
Glycogen synthase kinase-3 (GSK3) are ubiquitously expressed serine-threonine kinases involved in a plethora of functions ranging from the control of glycogen metabolism to transcriptional regulation. We recently demonstrated that GSK3 inhibition triggers JNK-cJUN-dependent apoptosis in human pancreatic ...
Glycogen Synthase Kinase Inhibitor (2'Z,3'E)-6-Bromo-indirubin3'-Oxime Enhances Drug Resistance to 5-FluorouracilChemotherapy in Colon Cancer Cells Kun-ping Liu,Feng Luo,Si-ming Xie,... - 《Chinese Journal of Cancer Research》 - ...
GSK3β Inhibitor VIII is an ATP-competitive inhibitor of the serine/threonine kinase, glycogen synthase kinase 3β (Ki = 38 nM; IC50 = 104 nM).{24857} It does not significantly inhibit the closely related cyclin-dependent kinase (Cdk)2 or Cdk5 (Kis = > 100 μM).{24857} GSK3β Inhib...
Glycogen synthase kinase (GSK3), a serine/threonine-protein kinase with two functionally distinct isoforms, α and β, was discovered in the context of glycogen metabolism and has emerged as a ubiquitous regulator of multiple signaling pathways19,20. Historically, GSK3β has been thought of as ...
Glycogen synthase kinase3β inhibitor reduces LPSinduced acute lung injury in mice Glycogen synthase kinase3β inhibitor reduces LPSinduced acute lung injury in miceWnt signaling, inflammation, neutrophil, cytokine, respiratory distress syndrome... Q Ding,G Liu,Y Zeng,... - 《Molecular Medicine ...
V. et al. 9-ING-41, a small-molecule glycogen synthase kinase-3 inhibitor, is active in neuroblastoma. Anti-cancer drugs 29, 717–724 (2018). CAS PubMed PubMed Central Google Scholar Wu, X. et al. Targeting glycogen synthase kinase 3 for therapeutic benefit in lymphoma. Blood 134, ...
Glycogen_synthase_kinase_3抑制剂_激动剂_MCE GSK-3 Glycogen synthase kinase 3 kinase that mediates the addition of phosphate molecules onto serine and threonine amino acid residues. In mammals GSK-3 is encoded by two known genes, GSK-3 alpha (GSK3A) and GSK-3 beta (GSK3B).GSK-3 has ...