Amylin activates glycogen phosphorylase and inactivates glycogen synthase via a cAMP-independent mechanism. Biochemical and Biophysical Research Communications . 1991; 174 (2):716–720.DEEMS R.O., DEACON R.W., YOUNG D.A. Amylin activates glycogen phosphorylase and inactivates glycogen synthase via ...
Glycogen synthase is post-translationally modified by phosphorylation that directly inhibits the enzyme. An increase in this ratio reflects a decrease in the phosphorylation state of glycogen synthase. Assays for Key Enzymes in Glycogen Metabolism Glycogen phosphorylase (GP) was prepared as previously ...
(3) The PGPH-2-mediated regulation of the HLH-30 nuclear translocation, autophagy and protection from glucotoxicity depend on the chronic glycogen breakdown by glycogen phosphorylase. Fig. 8: Graphical representation of the study findings. In this work, we unveil the mechanism whereby G3PP ...
Related to Glycogen phosphorylase:glycogen synthase phos·pho·ryl·ase (fŏs′fər-ə-lās′, -lāz′) n. Any of a class of enzymes that catalyze the attachment of a phosphate group to another molecule. American Heritage® Dictionary of the English Language, Fifth Edition. Copyright ...
The activities of glycogen synthase and glycogen phosphorylase were quantitated in liver and skeletal muscle removed following glucose infusion in hemodynamically stable endotoxin-treated rats. Four hours after the IV injection of endotoxin or saline, rats were infused with 235 mumole/min/kg of glucos...
1.Objective:To establish the colloid gold immunochromatographic assay for human cardiac tropinin I(cTnI) and glycogen phosphorylase isoenzyme BB(GPBB).目的:建立人心肌肌钙蛋白I(cTnI)及糖原磷酸化酶同工酶BB(GPBB)的胶体金免疫层析联合检测法。 4)phospho-glycogen synthase kinase-3 beta(P-GSK-3β)磷...
Eleven renal clear cell carcinomas were investigated with regard to their glycogen and glucose 6-phosphate (G6P) content and the activities of glycogen synthase and phosphorylase. Compared to normal cortex from the same kidneys, all tumours revealed increased glycogen and G6P content. The activities...
The molecular mechanism by which adrenalin inhibits glycogen synthesis Prior phosphorylation of the serine residue N7 by phosphorylase kinase increased sixfold the rate of phosphorylation of glycogen synthase by CK1, and altered... S Nakielny,DG Campbell,P Cohen - 《European Journal of Biochemistry》...
synthase by vasopressin, angiotensin II, and α-adrenergic agonists. Casein kinase I and GSK-3 have also been found in liver, and there are undoubtedly other hepatic glycogen synthase kinases. As in muscle, hepaticphosphorylase kinaseis probably not important as a glycogen synthase kinasein vivo,...
When blood glucose levels decrease, glucagon inhibits glycogen synthase and activates glycogen phosphorylase for the breakdown of glycogen in the liver. Epinephrine also activates glycogen breakdown in both the liver and skeletal muscle. View chapterExplore book...