Also provided herein are methods of preparing compounds of formula (F). Also provided herein are methods of inhibiting GYS1 and methods of treating a GYS1 -mediated disease, disorder, or condition in an individual in need thereof.
Previous reports have shown that heparin is an inhibitor of casein kinase-2 (CK-2). It is unclear whether heparin is also an inhibitor of glycogen synthase (casein) kinase-1 (CK-1), a type 1 casein kinase. In this study it is shown that CK-1 is potently inhibited by heparin when ph...
However, the studies reported here demonstrate proof of concept for GYS1 knockdown as a therapeutic approach for Pompe disease if these limitations can be overcome. For example, Pompe patients might be treated effectively with a combination of rhGAA and a PPMO-based glycogen synthase inhibitor ...
Glycogen synthase kinase-3 (GSK-3; sites C30, C34, C38 and C42; also phosphorylates inhibitor-2 (see below), thereby activating protein phosphatase-1). 5 Glycogen synthase kinase-4 (GSK-4; site N7; relatively specific for glycogen synthase). 6 Casein kinase-2 (site C46; broadly specific...
Glycogen synthase kinase (GSK) inhibition produced by ischemic preconditioning has been previously shown to be regulated through phosphatidylinositol-3 kinase (PI3K). Therefore, we determined whether opioid-induced cardioprotection (OIC) occurs during reperfusion by altering GSK phosphorylation through PI3K an...
et al. The metabolite alpha-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR. Nature 510, 397–401 (2014). CAS PubMed PubMed Central ADS Google Scholar Wu, N. et al. The metabolite alpha-ketobutyrate extends lifespan by promoting peroxisomal function in C. elegans. Nat. ...
5) Glycogen synthase kinase 3 糖原合成酶激酶3 1. To investigate the effect of lithium on celluar proliferation and transcription of Polo-like kinase 1(Plk1)in lung cancer cells,A549 cells were treated with lithium chloride(LiCl),a highly selective inhibitor of glycogen synthase kinase 3(GSK3...
Cellular glycogen deposits have been described in pathologic conditions such as diabetes or aging1,2,3,5. Genetic ablation of glycogen synthase in neurons improves neurologic function with age and extends life-span3. Evidence in the literature has therefore indicated that glycogen accumulation in ...
Glycogen Synthase Peptide-2 (Ala21)会员价请登录市场价￥2246原厂型号 12-242 雷琪货号 RH168294 品牌 默克密理博/Millipore 单件重量 1kg 货期 15天 单位: 盒 包装: 盒 库存: 0 数量: 盒 + - 1盒起订,增量1盒 加入购物车立即购买 累计成交0笔0条评价 选择其它规格 商品名 雷琪货号 原厂编号...
Glycogen Synthase Peptide-2 (Ala21) 会员价请登录市场价￥2246 原厂型号12-242 贝雷猫货号RH168294 品牌默克密理博/Millipore 单件重量1kg 货期15天 单位:盒包装:盒库存:0 数量:盒+-1盒起订,增量1盒 累计成交0笔0条评价 选择其它规格 商品名 贝雷猫货号 ...