Glycogen synthase kinase-3: functions in oncogenesis and development . Biochim Biophys Acta 1114 : 147 – 162 .Plyte, S.E., Hughes, K., Nikolakaki, E., Pulverer, B.J., Woodgett, J.R., 1992. Glycogen synthase kinase-3: functions in oncogenesis and devel- opment. Biochim. Biophys....
Loss of glycogen synthase kinase 3β (GSK-3β) in mice results in embryonic lethality via hepatocyte apoptosis. Consistent with this result, cells from these mice have diminished nuclear factor κB (NF-κB) activity, implying a functional role for GSK-3β in regulating NF-κB. Here, we have...
Loss of glycogen synthase kinase 3β (GSK-3β) in mice results in embryonic lethality via hepatocyte apoptosis. Consistent with this result, cells from these mice have diminished nuclear factor κB (NF-κB) activity, implying a functiona... KA Steinbrecher,W Wilson,PC Cogswell,... - 《Molec...
We report here that PAX3-FOXO1 enhances glycogen synthase kinase 3b (GSK3b) activity which in turn represses MYOGENIN activity. MYOGENIN is a GSK3b substrate in vitro on the basis of in vitro kinase assays and MYOGENIN is phosphorylated in ARMS-derived RH30 cells. Constitutively active GSK3b(...
Plant glycogen synthase kinase 3/SHAGGY-like kinases (GSKs) are important regulators of development, stress and hormone signaling. The identification of the nuclear proteins BES1 and BZR1 as substrates for BIN2 points to an important role for plant GSKs in transcriptional regulation.关键词:Plant...
Molecular Biomedicine (2022) 3:43 https://doi.org/10.1186/s43556-022-00111-1 Molecular Biomedicine RESEARCH Open Access Inhibition of glycogen synthase kinase‑3‑beta (GSK3β) blocks nucleocapsid phosphorylation and SARS‑CoV‑2 replication Tirosh Shapira1,2 , Selvarani ...
Glycogen synthase kinase-3β (GSK3β) was named for its ability to phosphorylate, and thereby inactivate, glycogen synthase, a key regulatory process in the synthesis of glycogen. With such an inauspicious beginning and moniker, it has come as some surprise to find that GSK3β is a critical...
Neural crest migration is critical to its physiological function. Mechanisms controlling mammalian neural crest migration are comparatively unknown, due to difficulties accessing this cell population in vivo. Here we report requirements of glycogen synthase kinase 3 (GSK3) in regulating the neural crest ...
Glycogen Synthase Kinase-3β Inhibition Augments Diabetic Endothelial Progenitor Cell Abundance and Functionality via Cathepsin B: A Novel Therapeutic Oppo... Progenitor cell therapy is hindered in patients with diabetes mellitus (DM) due to cellular senescence. Glycogen synthase kinase-3β (GSK3β) ...
Glycogen Synthase Kinase 3 Is an Insulin-Regulated C/EBPα Kinase CCAAT/enhancer binding protein alpha (C/EBPalpha) is a transcription factor involved in creating and maintaining the adipocyte phenotype. We have shown pre... SE Ross,RL Erickson,N Hemati,... - 《Molecular & Cellular Biology》...