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“GLP-1R阳性神经元在小鼠外侧隔核介导利拉鲁肽的厌食和降低体重效应(GLP-1R–positive neurons in the lateral septum mediate theanorectic and weight-lowering effects of liraglutide in mice)”的研究论文,文章主要研究了利拉鲁肽(一种GLP-1类似物,用于治疗肥胖症)在小鼠体内的厌食和降重效果,特别是研究了...
GLP-1R–positive neurons in the lateral septum mediate the anorectic and weight-lowering effects of liraglutide in micedoi:10.1172/JCI178239Liraglutide, a glucagon-like peptide-1 (GLP-1) analog, is approved for obesity treatment, but the specific neuronal sites that contribute to its therapeutic ...
百奥动物BioMice自主开发了B-hGCGR小鼠和B-hGLP1R小鼠,为糖尿病相关药物研究提供有效模型。 B-hGCGR小鼠 GCGR编码胰高血糖素受体,在控制血糖水平方面很重要。该基因的缺陷是非胰岛素依赖型糖尿病(NIDDM)的一个原因。人胰高血糖素受体(GCGR)通过其内源性配体胰高血糖素激活,在禁食期间触发肝脏释放葡萄糖,使其成为...
中国科学院深圳先进技术研究院脑认知与脑疾病研究所的朱英杰团队在《The Journal of Clinical Investigation》期刊上发表了一篇题为“GLP-1R–posIT(http://www.maoyihang.com/sell/l_25/)ive neurons in the lateral septum mediate the anorectic and weight-lowering effects of liraglutide in mice”的研究论文。
Cardiac function in mice lacking the glucagon-like peptide-1 receptor[J]. Endocrinology, 2003, 144 :2242-2252. [48]Laviola L, Leonardini A, Melchiorre M, et al. Glucagon-like peptide-1 counteracts oxidative stress-dependent apoptosis of human cardiac progenitor cells by inhibiting the ...
2023年7月10日,澳大利亚新南威尔士大学的研究人员在Cell子刊Cell Metabolism上发表了题为:“GDF15 enhances body weight and adiposity reduction in obese mice by leveraging the leptin pathway”的文章。 该文章揭示GDF15能通过瘦素通路增强对肥胖小鼠的体重和脂肪减少作用,后脑(hindbrain)中的瘦素信号通路增强了GDF15...