他们的成果发表在最新一期的Science杂志上，名为 “GLP-1 increases preingestive satiation via hypothalamic circuits in mice and humans”摄入前饱足是动物在食物摄入前对内部状态的调节反应，常由外部线索触发，能覆盖天生的饥饿和饱腹信号。此反应涉及食物的期待、思考及口感刺激，由特定神经通路调节，但具体通路尚...
[7]. Rakipovski G, Rolin B, Nøhr J, et al. The GLP-1 Analogs Liraglutide and Semaglutide Reduce Atherosclerosis inApoE-/- and LDLr-/- Mice by a Mechanism That Includes Inflammatory Pathways. JACC Basic Transl Sci. 2018 N...
[12]Noyan-Ashraf, M.H., Momen, M.A., Ban, K., Sadi, A.M., Zhou, Y.Q., Riazi, A.M., et al. 2009. GLP-1R agonist liraglutide activates cytoprotective pathways and improves outcomes after experimental myocardi...
近日,来自韩国首尔大学医学院生物医学科学系的Hyung Jin Choi团队,在Science杂志上,发表了题为GLP-1 increases preingestive satiation via hypothalamic circuits in mice and humans的文章,报道了肠促胰素GLP-1通过作用于下丘脑背内侧核中表达GLP-1受体的神经元与弓状核神经肽Y/刺鼠相关肽神经元之间形成的回路,增强...
Area (VTA) Inhibit Ghrelin-Stimulated Appetitive Reward. Int J Mol Sci. 2019;20(4). [7] Chang CJ, Lin CS, Lu CC, et al. Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota. Nat Commun. 2015; 6:7489. [8] Câmara NO, Iseki K, Kramer H,...
北京大学第三医院庞艳莉、乔杰、姜长涛、李蓉团队(云楚宇、闫森为第一作者)在 Nature 子刊 Nature Metabolism 上发表了题为:The microbial metabolite agmatine acts as anFXRagonist to promote polycystic ovary syndrome in female mice 的研究论文。 该研究发现肠道微生物普通拟杆菌(Bacteroides vulgatus)代谢物胍基丁胺...
近日,来自韩国首尔大学医学院生物医学科学系的Hyung Jin Choi团队,在Science杂志上,发表了题为GLP-1 increases preingestive satiation via hypothalamic circuits in mice and humans的文章,报道了肠促胰素GLP-1通过作用于下丘脑背内侧核中表达GLP-1受体的神经元与弓状核神经肽Y/刺鼠相关肽神经元之间形成的回路,增强...
[7] Chang CJ, Lin CS, Lu CC, et al. Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota. Nat Commun. 2015; 6:7489.[8] Câmara NO, Iseki K, Kramer H, et al. Kidney disease and obesity: epidemiology, mechanisms and treatment. Nat Rev...
近日,来自韩国首尔大学医学院生物医学科学系的Hyung Jin Choi团队,在Science 杂志上,发表了题为GLP-1 increases preingestive satiation via hypothalamic circuits in mice and humans的文章,报道了肠促胰素GLP-1通过作用于下丘脑背内侧核中表达GLP-1受体的神经元与弓状核神经肽Y/刺鼠相关肽神经元之间形成的回路,增...
一篇题为“Implantation of CPT1AM-expressing adipocytes reduces obesity and glucose intolerance in mice”的文章显示,科研人员旨在产生表达组成型活性CPT1A形式(CPT1AM)的脂肪细胞,该脂肪细胞可以改善小鼠植入后的肥胖表型。他们将脂肪组织来源的间充质干细胞(AT-MSCs)分化为成熟的脂肪细胞,再利用慢病毒介导CPT1AM...