[15] Bitsi, Stavroula, et al. "Divergent acute versus prolonged pharmacological GLP-1R responses in adult β cell–specific β-arrestin 2 knockout mice." Science Advances 9.18 (2023): eadf7737.[16] Challa, Tenagne Delessa, et al. "Regulation of adipocyte formation by GLP-1/GLP-1R sign...
GLP-1 receptor knockout miceGlucagonInsulin secretionTo study whether activation of GLP-1 receptors importantly contributes to the insulinotropic action of exogenously administered glucagon, we have performed whole animal experiments in normal mice and in mice with GLP-1 receptor knockout. Glucagon (1,...
目录号 NM-KO-190803 品系状态 活体 导出PDF 基因信息 基因名 Glp1r 基因曾用名 GLP-1R; GLP1Rc 染色体位置 17 NCBI ID 14652 MGI ID 99571 Ensembl ID ENSMUSG00000024027 Pubmed Glp1r 人类同源基因 GLP1R 品系描述 Exon 2 of Glp1r gene was deleted to generate Glp1r knockout mice. ...
[15] Bitsi, Stavroula, et al. "Divergent acute versus prolonged pharmacological GLP-1R responses in adult β cell–specific β-arrestin 2 knockout mice." Science Advances 9.18 (2023): eadf7737. [16] Challa, Tenagne Delessa, et al. "Regulation of adipocyte formation by GLP-1/GLP-1R sign...
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The fact that GLP-1 receptor knockout mice display reduced expression of genes responsible for endothelial protection and repair compared with wild type mice [48] makes it potentially interesting to investigate the interplay between gut GLP-1 and 5-HT in relation to the paracrine modulation of ...
(CYP27A1), two enzymes responsible for cholesterol metabolism, is a common feature of patients with NAFLD/NASH resulting in a decreased free cholesterol efflux [26]. Recently developed farnesoid X receptor (FXR) knockout (KO) mice were shown to have the histological characteristics of NASH: ...
After 5 consecutive days of tamoxifen injection followed by a 2-week waiting period to allow for degradation of pre-existing EGFR, the majority of the EGFR in the β-cell specific EGFR knockout mice is gone as shown previously8. Tamoxifen injection in adult mice to activate the Cre system ...
Wild-type (C57BL/6 J), global (Glp1r−/−), as well as endothelial (Glp1rflox/ floxxCdh5cre) and myeloid cell–specific knockout mice (Glp1rflox/ floxxLysMcre) of the GLP-1R Liraglutide Improvement in blood pressure and cardiac hypertrophy Reduction in cardiac and whole blood oxidative...
Nagashima M, Watanabe T, Terasaki M, Tomoyasu M, Nohtomi K, Kim-Kaneyama J, et al. Native incretins prevent the development of atherosclerotic lesions in apolipoprotein E knockout mice. Diabetologia. 2011;54:2649–59. ArticleCASPubMedPubMed CentralGoogle Scholar ...