[7]. Rakipovski G, Rolin B, Nøhr J, et al. The GLP-1 Analogs Liraglutide and Semaglutide Reduce Atherosclerosis inApoE-/- and LDLr-/- Mice by a Mechanism That Includes Inflammatory Pathways. JACC Basic Transl Sci. 2018 N...
他们的成果发表在最新一期的Science杂志上，名为 “GLP-1 increases preingestive satiation via hypothalamic circuits in mice and humans”摄入前饱足是动物在食物摄入前对内部状态的调节反应，常由外部线索触发，能覆盖天生的饥饿和饱腹信号。此反应涉及食物的期待、思考及口感刺激，由特定神经通路调节，但具体通路尚...
GLP-1(7-36酰胺)相对于exendin-4具有更好的心脏保护作用,且GLP-1(7-36酰胺)对GLP-1R敲除小鼠具有保护作用而并非exendin-4提示GLP-1(7-36酰胺)的部分心脏保护作用是独立于GLP-1R信号通路,并可能通过DPP-4-裂解GLP-1的代谢产物GLP...
一篇题为“Implantation of CPT1AM-expressing adipocytes reduces obesity and glucose intolerance in mice”的文章显示,科研人员旨在产生表达组成型活性CPT1A形式(CPT1AM)的脂肪细胞,该脂肪细胞可以改善小鼠植入后的肥胖表型。他们将脂肪组织来源的间充质干细胞(AT-MSCs)分化为成熟的脂肪细胞,再利用慢病毒介导CPT1AM...
近日,来自韩国首尔大学医学院生物医学科学系的Hyung Jin Choi团队,在Science杂志上,发表了题为GLP-1 increases preingestive satiation via hypothalamic circuits in mice and humans的文章,报道了肠促胰素GLP-1通过作用于下丘脑背内侧核中表达GLP-1受体的神经元与弓状核神经肽Y/刺鼠相关肽神经元之间形成的回路,增强...
[7] Chang CJ, Lin CS, Lu CC, et al. Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota. Nat Commun. 2015; 6:7489.[8] Câmara NO, Iseki K, Kramer H, et al. Kidney disease and obesity: epidemiology, mechanisms and treatment. Nat Rev...
“一专多能”的GLP-1受激动剂(GLP-1RA)/ GLP-1类似物在肥胖、糖尿病、非酒精性脂肪肝、心血管疾病和神经系统疾病等治疗领域中发挥不同作用。GLP-1受激动剂(GLP-1RA)/ GLP-1类似物的仿制药、创新药、复方制剂具有广阔的市场前景。 耀海生物,深耕微生物表达体系CRDMO服务,依托公司成熟完善的微生物合成表达平台...
近日,来自韩国首尔大学医学院生物医学科学系的Hyung Jin Choi团队,在Science 杂志上,发表了题为GLP-1 increases preingestive satiation via hypothalamic circuits in mice and humans的文章,报道了肠促胰素GLP-1通过作用于下丘脑背内侧核中表达GLP-1受体的神经元与弓状核神经肽Y/刺鼠相关肽神经元之间形成的回路,增...
[13] Teta, M., Long, S.Y., Wartschow, L.M., Rankin, M.M., Kushner, J.A. 2005. Very slow turnover of beta-cells in aged adult mice. Diabetes 54:2557-2567. [14] Bonner-Weir, S. 2001. beta-cell turnover: its assessment and implications. Diabetes 50 Suppl 1:S20-24. ...
[14] Kuhre, R.E., Gribble, F.M., Hartmann, B., Reimann, F., Windelov, J.A., Rehfeld, J.F., et al.2014. Fructose stimulates GLP-1 but not GIP secretion in mice, rats, and humans. Am J Physiol Gastrointest Liver Physiol 306:G622-630. ...