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In this study, we examined the effects of high glucose on the expression of GLP and its signaling pathways in the HBZYat mesangial cell line. We found that high glucose reduced GLP mRNA levels in HBZYcells and in the renal cortex in db/db mice comparing with control groups. In consistence...
ELISA assay was used to detect the expression of bone formation indexes [bone specific alkaline phosphatase (BALP),osteoprotegerin(OPG)] and bone resorption indexes [tartrate resistant acid phosphatase (TRAP)and C-terminal cross-linked peptide of type Ⅰ collagen (CTX-Ⅰ)]. Three-point bending ...
敲除Glp1r基因exon 2,建立Glp1r基因敲除小鼠模型。 应用领域:II型糖尿病相关 *使用本品系发表的文献需注明: Glp1r-KO mice (Cat. NO. NM-KO-190803) were purchased from Shanghai Model Organisms Center, Inc.. 鉴定方案 验证数据 Fig.1 Detection of Glp1r expression in lung by RT-PCR. ...
Interestingly, ablating GLP-1-expressing NTS neurons fails to prevent the appetite-suppressing effects of systemic liraglutide and semaglutide in mice [74], which is consistent with the lack of GLP-1R expression in these cells [75, 76]. Considering that systemic GLP-1R agonists and central GLP-...
敲除Glp1r基因exon 2,建立Glp1r基因敲除小鼠模型。 应用领域:II型糖尿病相关 *使用本品系发表的文献需注明: Glp1r-KO mice (Cat. NO. NM-KO-190803) were purchased from Shanghai Model Organisms Center, Inc.. 鉴定方案 验证数据 Fig.1 Detection of Glp1r expression in lung by RT-PCR. ...
The regions within the N-terminus critical for human glucagon like peptide-1 receptor(hGLP-1R) cell surface expression[J]. Scientific Reports, 2014, 4 :7410. [14]Huang Y, Wilkinson GF, Willars GB. Role of the signal peptide in the synthesis and processing of the glucagon-like peptide-1 ...