Besides, this study validated that [F]DPA-714 and [F]exendin-4 PET have the potential for noninvasive evaluation of microglial activation and GLP-1R expression in the brain of depression.doi:10.1038/s41398-020-01155-zYu LiuLizhen Wang
[19] Gosmain, Y., Cheyssac, C., Heddad Masson, M., Dibner, C., Philippe, J. 2011. Glucagon gene expression in the endocrine pancreas: the role of the transcription factor Pax6 in alpha-cell differentiation...
b, Representative images of Glp1r expression (RNAin situhybridization) in the DVC, ARC, and NG of control mice or mice with GLP1R neuron ablation in each region.c, Quantification of Caspase3- or DTA-mediated neural ablation: relative number (to controls) of GLP1R+ neurons in DVC (left),...
The very high concentration of GLP-1R-profiles in the circumventricular organs and in the ARC and NTS suggests that peripheral GLP-1 may influence brain functions via these brain areas.Similar content being viewed by others Expression of glucagon-like peptide 1 receptor in neuropeptide Y neurons ...
GLP-1R/CRE (Luc) Reporter – HEK293 Recombinant Cell Line Recombinant HEK293 cells expressing firefly luciferase gene under the control of cAMP response element (CRE) with constitutive expression of human GLP-1R (Glucagon-like peptide 1 receptor; accessi
Brain areas participating in the ability of these gut-brain peptides to reduce alcohol-mediated behaviors/neurochemistry involve those important for reward. Human studies support these preclinical studies as polymorphisms of the genes encoding for GLP-1 receptor or the ghrelin pathway are associated ...
H. Single-cell mapping of GLP-1 and GIP receptor expression in the dorsal vagal complex. Diabetes 70, 1945–1955 (2021). Article CAS PubMed PubMed Central Google Scholar Download references Acknowledgements We thank M. Dietrich and H. Grill for comments on the manuscript; B. Arenkiel and...
Gene expression analysis within the adrenals revealed the upregulation of Insr and the downregulation of Prgtr in HFD mice, while Ex-4 downregulated the expression of Gipr. The ovarian gene expression of Gipr, Npy1r and Prgtr was downregulated by Ex-4 treatment, while PYY(3–36) ...
Immunohistochemical studies in monkeys and humans found GLP-1R+ cells mainly in the sinoatrial node and atrial tissue, with higher expression in the right atrium. However, varied detection methods show inconsistent GLP-1R localization across heart tissues. While murine models suggest atrial GLP-1R ...
The vagus nerve of the parasympathetic nervous system richly innervates the gastrointestinal tract where it controls various digestive processes ranging from gastric acid secretion to peristalsis [22]. Based mainly on receptor transcript expression in the nodose ganglia, where the cell bodies of vagal ...