the precise central mechanisms of GLP-1RAs remain elusive. We administered GLP-1RAs to obese patients and observed heightened sense of preingestive satiation. Analysis of human and mouse brain samples pinpointed GLP-1R neurons in the dorsomedial hypothalamus (DMH) as candidates for encoding pre...
Wettergren, A., Svendsen, L.B., et al. 2013. The effect of exogenous GLP-1 on food intake is lost in male truncally vagotomized subjects with pyloroplasty. Am J Physiol Gastrointest Liver Physiol 304:G1117-1127.
Glucagon-like peptide-1 (GLP-1) injected into the brain reduces food intake. Similarly, activation of preproglucagon (PPG) cells in the hindbrain which synthesize GLP-1, reduces food intake. However, it is far from clear whether this happens because of satiety, nausea, reduced reward, or ...
Unigene: 45494 Mouse Unigene: 54383 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 胰高血糖素(Glucagon)在糖代谢和体内平衡中起重要作用,通过释放糖原和糖酵解调节血糖。作为反调节激素的胰岛素,当血糖升高时,...
Pre-weighed food was returned immediately before dark onset, and intake was measured 1, 2, 4, and 22 h later. Each mouse received both a no-stress control and stress treatment, so this experiment had a mixed between/within-subjects design. Body weight was recorded daily, but as no effect...
胰高血糖素样肽-1(Glucagon-like peptide-1,GLP-1)是胰高血糖素前驱体的一部分。胰高血糖素前驱体于胰脏、小肠下部以及下丘脑中表达。该前驱体的构造中含有与糖代谢有关的各种各样的生理活性物质(胰高血糖素,肠高血糖素,胃泌酸调节素,GLP-1,GLP-2)的氨基酸序列。根据表达部位加工酶的特异性,胰脏主要分泌胰...
Glucagon-like peptide-1 (GLP-1) released from gut enteroendocrine cells controls meal-related glycemic excursions through augmentation of insulin and inhibition of glucagon secretion. GLP-1 also inhibits gastric emptying and food intake, actions maximizing nutrient absorption while limiting weight gain. ...
Interestingly, the food intake-suppressing effect of GLP-1 administered intraperitoneally was abolished in a mouse lacking 5-HT2C receptors, suggesting a link between GLP-1 and serotonergic regulation of food intake [31], [32]. PPG neurons heavily innervate serotonergic neurons in the caudal raphe ...
The mice were then weighed, and each mouse received an oral gavage of D-glucose solution (1 g/kg) dissolved in sterile saline. Blood glucose levels were measured at 15, 30, 60, 90, and 120 min after administration of the D-glucose solution. Insulin tolerance tests (ITT) For the ...
The roles of glucagon-like peptide-1(GLP-1) receptor agonist includes enhancing glucose dependent insulin secretion,inhibiting glucose dependent glucagon secretion,delaying gastric emptying,reducing appetite,food intake and body weight. These drugs can reduce the level of C reactive protein and improve ...