首先来看Glucagon-like peptide 1(GLP-1)多肽的序列。真正具有活性的GLP-1多肽,指的是GLP-1(1-37或1-36)在经过N-端六肽的切割之后形成的活性片段GLP-1(7-36, 7-37)(下称GLP-1)。GLP-1活性多肽,之所以不稳定,主要在于GLP-1(7-36, 7-37)的N-端二肽被DPP-4酶(二肽基肽酶4)降解。GLP-1被DDP-4...
葡萄糖依赖性促胰岛素释放多肽受体(Glucose-dependent insulinotropic polypeptide receptor,GIPR)、胰高血糖素样肽-1受体(Glucagon-like peptide-1 receptor,GLP-1R)和胰高血糖素受体(Glucagon receptor,GCGR)是调节糖脂和氨基酸代谢的B1类...
作者: 胰高血糖素样肽-1(Glucagon-likepeptide-1,GLP-1)是一种内源性肠促胰岛素激素,由31个氨基酸残基组成,由胰高血糖素原基因转录、翻译及加工而成。GLP-1具有葡萄糖浓度依赖性降糖作用,其受体激动剂(GLP-1RA)能够模拟GLP-1的生理作用,是降糖和减重药物研发的热门靶点。 GLP-1RA具有多重机制发挥降糖和减重功...
单纯的药物减肥看来并不是什么难事难的是如何在保证健康安全的前提下减肥多肽药物似乎给出了一个药物减肥的可行方案GLP-1(Glucagon-like peptide 1,胰高血糖素样1多肽)肩负了肥胖症患者的希望,尽管它们的出身并不是这个目的,而是II型糖尿病药物,但这...
[4]Müller TD,Finan B,Bloom SR,et al.Glucagon-like peptide 1(GLP-1).Mol Metab 2019;30:72-130. [5]Pelle MC,et al.Role of a Dual Glucose-Dependent Insulinotropic Peptide(GIP)/Glucagon-like Peptide-1 Receptor Agonist(Twincretin)in Glycemic Control:From Pathophysiology to Treatment.Life(Basel...
GLP - 1 药物司美格鲁肽:延缓衰老新希望 GLP - 1.全称 Glucagon - Like Peptide - 1.即胰高血糖素样肽 - 1.是肠促胰岛素的一种,主要由肠道 L 细胞产生。不少天然食物都能促进人体分泌 GLP - 1.它在人体内能抑制胃肠蠕动、延缓胃排空,并抑制食欲。
通过形成分子内桥或用酰胺基团取代末端羧酸进一步修饰所述胰高血糖素肽,产生表现出胰高血糖素/GLP-1受体共激动剂活性的肽. Intramolecular bridge is formed by or substituted with a terminal carboxylic acid amide group of said further modified glucagon peptides produced exhibits glucagon / GLP-1 receptor ...
GLP-1 受体激动剂的实践:患者、医生、运动员和运动营养学家的观点 胰高糖素样肽-1(Glucagon-like peptide-1,GLP-1)是一种主要由肠道L细胞所产生的激素,属于肠促胰素。它主要用于控制2型糖尿病患者的血糖水平,一些GLP-1激动剂也可以帮助治疗肥胖。 2005年首款GLP-1受体激动剂(艾塞那肽)问世,需每日两次注射...
5.A. S. Alexopoulos, J. B. Buse, Initial injectable therapy in type 2 diabetes: key considerations when choosing between glucagon-like peptide 1 receptor agonists and insulin.Metabolism,(2019). 6.A. C. Sposito, O Berwanger, LSF de Carvalho et al., GLP-1RAs in type 2 diabetes: mechan...
demonstrated that administration of Cb-GLP-1 effectively lowered blood glucose levels, regulated dyslipidemia, and ameliorated hepatic impairment in T2DM mice. Furthermore, Cb-GLP-1 treatment facilitated insulin secretion by retarding islet cell apoptosis and activating the glucagon-like peptide 1 receptor...