[2] Ma, X. et al. Glucagon-like peptide 1-potentiated insulin secretion and proliferation of pancreatic β-cells". Journal of Diabetes. 2014, 6, 394–402. [3] Gautier, J. F. et al. Physiology of incretins (GIP and GLP-1) and abnormalities in type 2 diabetes. Diabetes & Metabolism....
在此之前很多人认为GLP-1诱导饱腹感和抑制食欲是通过直接抑制中枢神经和延缓胃排空来实现的,而这项研究发现外源性补充全人源GLP-1可以降低两餐间隔期间饥饿素水平间接抑制食欲。 参考文献 Glucagon-like peptide 1 (GLP-1) suppresses ghrelin levels in humans via increased insulin secretion. Regul Pept. 2007 O...
[2] Ma, X. et al. Glucagon-like peptide 1-potentiated insulin secretion and proliferation of pancreatic β-cells". Journal of Diabetes. 2014, 6, 394–402. [3] Gautier, J. F. et al. Physiology of incretins (GIP and GLP-1) and abnormal...
[13] Shigeto, M.; Ramracheya, R.; Tarasov, A.I.; et al. GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation. J. Clin. Investig. 2015, 125, 4714–4728. [14] Shigeto, M.; Cha, C.Y.; Rorsman, P.; et al. A role of PLC/PKC-dependent pathway in...
[2] Ma, X. et al. Glucagon-like peptide 1-potentiated insulin secretion and proliferation of pancreatic β-cells". Journal of Diabetes. 2014, 6, 394–402. [3] Gautier, J. F. et al. Physiology of incretins (GIP and GLP-1) and abnormalities in type 2 diabetes. Diabetes & Metabolism...
LY2189265, a long-acting glucagon-like peptide-1 analogue, showed a dose-dependent effect on insulin secretion in healthy subjects. Diabetes Obes Metab 13:434-438. [32] Dungan, K.M., Povedano, S.T., Forst, T., Gonzalez, J.G., At...
LY2189265, a long-acting glucagon-like peptide-1 analogue, showed a dose-dependent effect on insulin secretion in healthy subjects. Diabetes Obes Metab 13:434-438. [32] Dungan, K.M., Povedano, S.T., Forst, T., Gonzalez, J.G., Atisso, C., Sealls, W., et al. 2014. Once-weekl...
8. Shigeto M, Ramracheya R, Tarasov AI, Cha CY, Chibalina MV, Hastoy B, Philippaert K, Reinbothe T, Rorsman N, Salehi A. GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation. J Clin Invest. 2015;125(12):4714–4728. doi: 10.1172/JCI81975. ...
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Inhibition of the in vitro secretion of insulin by an extract of pancreatic alpha-1 cells. Endocrinology 84:1484-1488.[7] Unger RH, Eisentraut AM, Mc CM, Keller S, Lanz HC, Madison LL,1959. Glucagon antibodies and their use for immunoassay for glucagon. Proc Soc Exp Biol Med 102:621-...