Deacon, CF, Plamboeck, A, Moller, S, Holst, JJ (2002) GLP-1-(9–36) amide reduces blood glucose in anesthetized pigs by a mechanism that does not involve insulin secretion. Am J Physiol Endocrinol Metab 282: pp. E873-E879Deacon CF, Plamboeck A, Moller S, Holst JJ. GLP-1-(9...
Acute 9-PAHSA Treatment Does Not Improve Glucose Tolerance or Stimulate Insulin and GLP-1 Secretion in Mice Fed Low- and High-Fat CN-Based Diets Male mice fed low-fat or high-fat CN-based diets for 20 weeks were administered vehicle or 9-PAHSA by oral gavage. 9-PAHSA plasma levels si...
In contrast, GIP did not stimulate recruitment of either GRK2 or Arr3 to its receptor. Interestingly, arrestin remained at the plasma membrane even after prolonged (30 min) stimulation with GLP-1. Although the GLP-1R/arrestin interaction could not be reversed by agonist washout, GLP-1R and ...
Although both stimulate insulin secretion, there are subtle differences between these two molecules. GLP-1 suppresses glucagon secretion, but GIP stimulate glucagon secretion. Currently, there is much interest in adding glucagon to incretins. However, glucagon has some untoward side effects and caution...
Moreover, intestinal microbiota has been shown to reduce the secretion of intestinal hormones such as peptide YY (PYY) and glucagon-like peptide-1 (GLP-1). These hormones play a pivotal role in regulating satiety, and their decreased secretion may lead to heightened food consumption [10]. ...
(a) ability to resist the low pH in the gut, undergo hydrolysis by enzymes, and absorption within the gut; (b) fermented by intestinal microflora; and (c) selectively stimulate the growth and activities of intestinal bacteria related to gut health and wellbeing of the host animal [106]. ...