胰岛素（Insulin）是人体中天然的降血糖物质，而胰高血糖素（Glucagon）则是升血糖物质，二者相互制衡，调...
Fujitani, Y., et al. 2009. Effects of exendin-4 on glucose tolerance, insulin secretion, and beta-cell proliferation depend on treatment dose, treatment duration and meal contents. Biochem Biophys Res Commun 390:809-814.
GLP‐1, in addition to its well‐characterized glycemic actions, improves endothelial function, increases muscle microvascular perfusion, and stimulates angiogenesis. Importantly, these actions are preserved in the insulin resistant states. Thus, treatment of insulin resistant patients with GLP‐1 receptor...
Fujitani, Y., et al. 2009. Effects of exendin-4 on glucose tolerance, insulin secretion, and beta-cell proliferation depend on treatment dose, treatment duration and meal contents. Biochem Biophys Res Commun 390:809-814.
[22] Chang, C.C., Lin, T.C., Ho, H.L., Kuo, C.Y., Li, H.H., Korolenko, T.A., et al. 2018. GLP-1 Analogue Liraglutide Attenuates Mutant Huntingtin-Induced Neurotoxicity by Restoration of Neuronal Insulin Signaling. Int...
DA. Dual GIP and GLP-1 Receptor Agonist Tirzepatide Improves Beta-cell Function and Insulin ...
In particular, glucagon-like peptide (GLP-1), a potent stimulus of insulin secretion, is being developed as a therapy for the treatment of non-insulin-dependent diabetes mellitus. To define structural moieties of the molecule that convey its insulinotropic activity, we have cloned and characterized...
激素原转化酶可将胰高糖素原分子切成不同大小的肽段,包括含肠高血糖素相关胰多肽(GRPP; 氨基酸片段1 - 30)、胰高糖素(氨基酸片段33 - 61)、胃泌酸调节素(OXM;氨基酸片段 33 - 69)的肠高血糖素(氨基酸片段1 - 69)和含胰高糖素样肽1 (GLP-1;氨基酸片段 72-107/108)、胰高糖素样肽2 (GLP-2;氨基...
GLP-1 is an incretin hormone released from enteroendocrine cells in response to eating that stimulates insulin secretion, slows gastric emptying and promotes satiety1,3. In addition, GLP-1 is also a neuropeptide produced by neurons in the lower brainstem4,5,6 that suppress eating in rodents7,8...
药物靶点作用机制在研适应症药物最高研发状态(全球)药物类型在研机构GMA102/105(重组抗人GLP-1受体人源化单克隆抗体)GIP-1RGIP-1R激动剂2型糖尿病;肥胖;超重临床3期单克隆抗体鸿运华宁(杭州)生物医药有限公司(Gmax Biopharm LLC)Recombinant GLP-1 receptor agonists (Beijing Lepu)(重组GLP-1受体激动剂GIP-1RG...