GLP-1也可能直接抑制胰高血糖素的分泌,因为与野生型对照相比,α细胞特异性GLP-1受体激动剂敲除小鼠非空腹胰高血糖素水平升高,而雌性α细胞特异性GLP-1受体激动剂敲除小鼠在外周给糖后胰高血糖素分泌增加,表现出轻度葡萄糖不耐受[66]。在使用胰岛素受体拮抗剂S961或生长抑素受体2拮抗剂CYN154806处理的离体人胰岛中,...
W., Nauck, M.A. 1996. Gastric emptying, glucose responses, and insulin secretion after a liquid test meal: effects of exogenous glucagon-like peptide-1 (GLP-1)-(7-36) amide in type 2 (noninsulin-dependent) diabetic patients. J Clin Endocrinol Metab 81:327-332. ...
GLP-1:functionalpancreaticeffectsGLP-1hasadirectfunction aleffectonpancreaticcells,influencingsecretionsfromalpha- ,beta-anddelta-cells.Oneofitsmostimportanteffectsisto increaseinsulinsecretion.Importantly,however,itsinsulinotr opicactionisglucosedependent.Consequently,GLP-1hasthecap acitytolowerbloodglucosewhilepro...
Fujitani, Y., et al. 2009. Effects of exendin-4 on glucose tolerance, insulin secretion, and beta-cell proliferation depend on treatment dose, treatment duration and meal contents. Biochem Biophys Res Commun 390:809-814.
LIRA-2011-9 利拉鲁肽 Victoza 胜利之药 * * β细胞的胰岛素脉冲式分泌和时相分泌共同维持着人体正常血糖水平,同时也受到血糖、血脂、β细胞凋亡与再生、细胞量及胰升血糖素样肽1(GLP-1)等诸多因素的影响。The incretin hormones play a crucial role in a healthy insulin response The effect of incretins ...
* GLP-1对人体生理具有多种直接和间接影响,靶向作用于胰腺、肝脏、心脏、胃肠系统、肾脏、脂肪细胞、肌肉和中枢神经系统。 * * PCP slide kit Post-Paris Draft 1 * GLP-1 increases insulin, and reduces glucagon, lowering glucose levels Nauck et al. Diabetologia 1993;36:741–4 ABSTRACT:Glucagon-like ...
Pulsatile insulin secretion was increased as measured by secretory burst mass (19.3 +/- 3.8 vs 53.0 +/- 10.7 pmol/l/ pulse, p = 0.02) and secretory burst amplitude (7.7 +/- 1.5 vs 21.1 +/- 4.3 pmol/l/min, p = 0.02). A similar increase in basal insulin secretion was observed (...
[54]Lovshin, J.A., Barnie, A., DeAlmeida, A., Logan, A., Zinman, B., Drucker, D.J. 2015. Liraglutide promotes natriuresis but does not increase circulating levels of atrial natriuretic peptide in hypertensive subjects with type 2 diabetes. Diabetes Care 38:132-139. ...
胰素:GLP-1及GIPGLP-1及GIP为体内两种主要的肠促胰素胰高糖素样肽1(GLP-1)主要由位于回肠和结肠的L细胞 合成和分泌作用于体内多个部位:胰腺β细胞和α细胞、胃肠道、中枢神经系统及心脏等其作用是通过特异受体介导的葡萄糖依 赖的促胰岛素分泌多肽(GIP)(亦称抑胃肽)主要由位于十二指肠和空肠的K细胞合成和分泌...
本期特邀北京大学第一医院霍勇教授带您从GLP-1对损伤后心脏功能的影响、心脏代谢功能的影响、心率/血压的影响等方面探寻其心血管保护作用的机制。一些研究报告称,急性或慢性GLP-1R激动作用导致啮齿动物血压升高…