Previous studies, using clinical trial data, demonstrated that once-weekly (OW) semaglutide is dominant versus other glucagon-like peptide 1 receptor agonists (GLP-1 RAs) in China. This study aims to evaluate the long-term clinical and economic effects of switching to OW semaglutide from other ...
Our findings also revealed a gradual metabolic shift from glycolysis, during the initial four stages of pancreatic progenitor formation, to oxidative phosphorylation later on during endocrine differentiation. Furthermore, the resulting insulin-producing cells exhibited a response to several secretagogues, ...
No new safety concerns were identified; 3% discontinued due to AEs, 2% reported ≥1 hypoglycemic episode (blood glucose <54 mg/dL) and 8/11 participants with ≥1 level 2 hypoglycemic episode were on insulin.In adults with T2D previously treated with GLP-1RAs, switching to OW semaglutide may...
Thus, we measured intestinal Foxp3 expression to determine if intestinal epithelial MyD88 influences immune tolerance in the intestine. It is well established that obesity is associated with a decrease in Tregs in adipose tissue contributing to inflammation and insulin resistance36. In this study, we...