[14] Shigeto, M.; Cha, C.Y.; Rorsman, P.; et al. A role of PLC/PKC-dependent pathway in GLP-1-stimulated insulin secretion. J. Mol. Med. 2017, 95, 361–368.
[80] Gudmundsdottir, V., Pedersen, H.K., Allebrandt, K.V., Brorsson, C., van Leeuwen, N., Banasik, K., et al. 2018. Integrative network analysis highlights biological processes underlying GLP-1 stimulated insulin secretion: A DIRECT study. PLoS One 13:e0189886. [81] Herzberg-Scha...
[35] Fridolf, T., Bottcher, G., Sundler, F., Ahren, B. 1991. GLP-1 and GLP-1(7-36) amide: influences on basal and stimulated insulin and glucagon secretion in the mouse. Pancreas 6:208-215. [36] Freyse, E.J., Becher, T., El-Hag, O., Knospe, S., Goke, B., Fischer,...
[35] Fridolf, T., Bottcher, G., Sundler, F., Ahren, B. 1991. GLP-1 and GLP-1(7-36) amide: influences on basal and stimulated insulin and glucagon secretion in the mouse. Pancreas 6:208-215. [36] Freyse, E.J., Be...
• Specific Aim #1. To identify genetic variants associated with effects of a GLP1R agonist to enhance glucose- stimulated first phase insulin secretion in the two FSIGTs (before and after administration of drug). •...
GLP-1 receptor activated insulin secretion from pancreatic β-cells: mechanism and glucose dependence. Diabetes Obes Metab. 2013 Jan;15(1):15-27. [4] Rameshrad M, Razavi BM, Lalau JD, De Broe ME, Hosseinzadeh H. An overview of glucagon-like peptide-1 receptor agonists for the treatment...
A Ca2+ signaling system stimulated by the insulinotropic hormone glucagon-like peptide-1-(7-37). J Biol Chem 274:14147-14156.[37] Kang G, Chepurny OG, Holz GG,2001. cAMP-regulated guanine nucleotide exchange factor II (Epac2) mediates Ca2+-induced Ca2+ release in INS-1 pancreatic beta...
[36] Holz GG, Leech CA, Heller RS, Castonguay M, Habener J F,1999. cAMPdependent mobilization of intracellular Ca2+ stores by activation of ryanodine receptors in pancreatic beta-cells. A Ca2+ signaling system stimulated by the insulinotropic hormone glucagon-like peptide-1-(7-37). J Biol ...
The influence of GLP-1 on glucose-stimulated insulin secretion: effects on beta-cell sensitivity in type 2 and nondiabetic subjects. Diabetes 52(2):380e386.Kjems LL, Holst JJ, Volund A, Madsbad S. The influ- ence of GLP-1 on glucose-stimulated insulin secretion: effects on beta-cell ...
[36] Holz, G.G., Leech, C.A., Heller, R.S., Castonguay, M., Habener, J.F. 1999. cAMPdependent mobilization of intracellular Ca2+ stores by activation of ryanodine receptors in pancreatic beta-cells. A Ca2+ signaling system stimulated by the insulinotropic hormone glucagon-like peptide-...