Insulin secretionGLP-1 receptorEndocytic traffickingReceptor signallingStimulation of insulin secretion by glucagon-like peptide-1 (GLP-1) and other gut-derived peptides is central to the incretin response to ingesting nutriments. Analogues of GLP-1, and inhibitors of its breakdown, have found ...
Cantley J. The control of insulin secretion by adipokines: current evidence for adipocyte-beta cell endocrine signalling in metabolic homeostasis. Mammalian Genome. 2014;25(9-10):442-454.The control of insulin secretion by adipokines: current evidence for adipocyte-beta cell endocrine signalling in ...
The Endocrine Pancreas and Control of Blood Glucose This chapter describes the histological arrangement of cells within the islets of Langerhans in the pancreas. It describes the chemical nature or insulin and the stimuli for its secretion by the 尾 cells of the islets. It shows the patte... ...
For example, gastrointestinal hormones such as glucagon-like peptide-1 (GLP-1) not only act as homeostatic signals that are involved in the control of meal size or body weight but also influence reward–based aspects of ingestive behavior [49], [50]. Food reward is often divided into two ...
Focuses on the multiple sites of purinergic control of insulin secretion in mouse pancreatic beta-cells. Glucose-induced insulin secretion reduced by extracellular ATP; Stimulatory effect of ATP; Importance of the inhibitory action of ATP for autocrine regulation of insulin secretion in mouse beta-cells...
Control of insulin secretion in pancreatic β-cells 来自 ResearchGate 喜欢 0 阅读量: 21 作者: O Petersen 摘要: Recent studies on single cells employing both fluorometric and electrophysiological techniques reveal new aspects of metabolic regulation of cellular Ca2+ handling. Glucose-evoked increase in ...
In control medium, glutamine alone was ineffective, but its combination with leucine or nonmetabolized 2-amino-bicyclo [2,2,1]-heptane-2-carboxylic acid (BCH) evoked rapid insulin secretion. The effect of BCH was larger in low glucose than in high glucose. In contrast, the insulin secretion...
What Is GLP-1? Glucose homeostasis is a complicatedprocess that involves insulin, as wellas amylin, glucagon, glucagon-likepeptide-1 (GLP-1), and glucose-dependentinsulinotropic polypeptide (GIP).GLP-1 is a peptide secreted by L cellsin the intestines with the ingestion offood. It increases ...
(GLP-1R, Y1-R, and Y2-R, respectively) elicit Y1-R antagonist-controlled, GLP-1R-dependent stimulation of insulin secretion in both rat and human pancreatic islets, thus revealing the counteracting effects of Y1-R and GLP-1R agonism. These agonists also promote insulin-independent Y1-R-...
The overwhelming increase in the prevalence of overweight and obesity in recent years represents one of the greatest threats to the health of the developed world. Among current treatments, however, gastrointestinal (GI) surgery remains the only approach