GLP-1 is a incretion hormone, which has been shown to stimulate secretion of insulin in the presence of elevated blood glucose concentrations, but not during periods of low blood glucose concentrations (hypoglycemia). GLP-1 is released from gut endocrine cells in response to nutrient ingestion....
GLP-1 stimulates insulin secretion, delays gastric emptying, decreases glucagon levels and reduces appetite, all resulting in a fall in plasma glucose concentrations. More recently, evidence suggests it can stimulate beta cell neogenesis and improve cardiovascular function, and may even be neuroprotective...
[12] Gevrey, J.C., Malapel, M., Philippe, J., Mithieux, G., Chayvialle, J.A., Abello, J., et al. 2004. Protein hydrolysates stimulate proglucagon gene transcription in intestinal endocrine cells via two ...
(上下滑动可查看) [1] Fujitani, Y. 2018. How does glucagon-like peptide 1 stimulate human beta-cell proliferation? A lesson from islet graft experiments. J Diabetes Investig 9:1255-1257. [2] Butler, A.E., Janson, J., Bonner...
[12] Gevrey, J.C., Malapel, M., Philippe, J., Mithieux, G., Chayvialle, J.A., Abello, J., et al. 2004. Protein hydrolysates stimulate proglucagon gene transcription in intestinal endocrine cells via two elements related to cyclic AMP response element. Diabetologia 47:926-936. ...
rations of GIP revealed that GIP could also stimulate insulin secretion in animals and humans. Because the inhibitory effect of GIP on gastric acid secretion was seen only at pharmacologic doses, whereas its incretin action occurred at physiologic levels, GIP was renamed glucose- dependent insulinotro...
They stimulate insulin secretion, inhibit glucagon release, and slow gastric emptying, potentially exerting protective effects on renal function13. Previous trials have demonstrated that GLP-1 RAs can reduce the risk of major adverse cardiovascular events (MACEs) and may have beneficial effects on ...
A study found that foods high in monounsaturated fats may stimulate GLP-1 secretion. Another study found that eating a whole avocado with a meal increased GLP-1 levels while also reducing insulin levels. In addition to the healthy fats in avocados, they are also high in fiber. High fiber ...
insulin secretion,but howdoes GLP・ 1(7・ 36)N]-12 stimulateinsulinsecretion?The answertothis question isfundamentalfortheassessmentofthe therapeuticpotential ofthe gut hormone.In this experimentradio-immunoassay and hybridization insitu were applied toobservethe insulinotropic activitiesofGLP-1 f7-36...
Interestingly, while GLP-1 is well known to stimulate insulin secretion by the pancreatic β-cells, direct evidence of CCK promoting insulin release in human islets remains to be determined. Here, we tested whether islet-derived GLP-1 or CCK is necessary for the full stimulation of insulin ...