① GTEx项目的主要目标是为一系列人体组织的所有基因鉴定eQTL ② 由于我们的样本量较小,因此我们主要研究了顺式作用于基因的eQTL(顺式eQTL;请参见框S1),因为反式eQTL的预期效应量(框S1)太小而无法在此有效检测到 ③ 我们针对每个基因的转录起始位点(TSS)的T1 Mb内的所有SNP,分别为具有足够样本量(> 80个供体)...
Design of the GTEx project The GTEx project of the NIH Common Fund aims to establish a resource database and associated tissue bank in which to study the relationship between genetic variation and gene expression and other molecular phenotypes in multiple reference tissues (Supplementary Fig. 1). ...
基因项目TheGTExthe基因表达 系统标签: gtextissueexpressiongenotypeprojecteqtls OPEN580volume45|NumBeR6|JuNe2013|naturegeneticscommentary(andeventuallycompletelysequenced),withgenotypingdatalinkedtogenome-widegeneexpressionpatternsacrossawiderangeo tis-suetypes.Initially,thisresourcewouldenabletheresearchcommunitytoper or...
机译:基因型 - 组织表达(GTEx)项目。 3. The Genotype-Tissue Expression (GTEx) project. [O] . Lonsdale, John, Thomas, Jeffrey, Salvatore, Mike, 机译:基因型 - 组织表达(GTEx)项目。 4. The Genotype-Tissue Expression (GTEx) project. [O] . Lonsdale, John, Thomas, Jeffrey, Salvatore, ...
TissueExpression(GTEx)project,whichwillestablisharesourcedatabaseandassociatedtissuebankforthescientificcommunitytostudytherelationshipbetweengeneticvariationandgeneexpressioninhumantissues.URLs.GWAS,http://.genome.gov/gwastudies;GTExLDACCDataPortal,http://.broadinstitute/gtex;caHUB,http://cahub.cancer.gov/;and...
The Genotype-Tissue Expression (GTEx) project is an NIH Common Fund study that is aimed at understanding how genetic variation influences gene expression in normal tissues. Here we describe a biospecimen collection platform that was deve... L Carithers,A Rao,H Moore - 《Cancer Research》 被引量...
The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humansUnderstanding the functional consequences of genetdoi:10.1126/SCIENCE.1262110American Association for the Advancement of ScienceScience
Farm animal Genotype-Tissue Expression (FarmGTEx) 项目致力于通过全球科学家的合作,为家养动物构建一个全面的分子表型QTL数据库,从而帮助我们更好地解析重要经济性状以及环境适应性的分子遗传机制,同时促进新的育种手段(比如基因编辑)和比较基因组学的发展。
Here we build a cattle Genotype-Tissue Expression atlas (cattleGTEx) as part of the pilot phase of Farm animal GTEx (FarmGTEx) project for the research community based on publicly available 7,180 RNA-Seq samples. We describe the landscape of transcriptome across over 100 tissues and report ...
In this study, 1573 differentially expressed genes, related to chronological age, from the Genotype-Tissue Expression (GTEx) project, were categorized as upregulated age-associated genes (UAGs) and downregulated age-associated genes (DAGs). Characteristics in evolution, expression, function and ...