此外,交叉引用具有疾病遗传关联的组织特异性eQTL可以帮助识别与疾病生物学最相关的组织。我们使用GTEx试点数据检查了多个组织之间的eQTL共享,并利用较大的组织范围发现了弱但具有组成型活性的eQTL ② 我们调查了九种组织中每种组织的22286个基因(至少10个样本中RPKM> 0.1)的eQTL共享模式,并对每对组织进行了基于模型的...
基因项目TheGTExthe基因表达 系统标签: gtextissueexpressiongenotypeprojecteqtls OPEN580volume45|NumBeR6|JuNe2013|naturegeneticscommentary(andeventuallycompletelysequenced),withgenotypingdatalinkedtogenome-widegeneexpressionpatternsacrossawiderangeo tis-suetypes.Initially,thisresourcewouldenabletheresearchcommunitytoper or...
The GTEx project of the NIH Common Fund aims to establish a resource database and associated tissue bank in which to study the relationship between genetic variation and gene expression and other molecular phenotypes in multiple reference tissues (Supplementary Fig. 1). The GTEx project began with...
Here we describe the Genotype-tissue expression (Gtex) project, which will establish a resource database and associated tissue bank for the scientific community to study the relationship between genetic variation and gene expression in human tissues.* A full list of members and affiliations appears ...
We present an analysis of RNA sequencing data from 1641 samples across 43 tissues from 175 individuals, generated as part of the pilot phase of the Genotype-Tissue Expression (GTEx...
The Genotype-Tissue Expression (GTEx) Project: Linking Clinical Data with Molecular Analysis to Advance Personalized Medicine Evaluation of how genetic mutations or variability can directly affect phenotypic outcomes, the development of disease, or determination of a tailored trea... JC Keen,HM Moore ...
Genotype-Tissue Expression (GTEx) 2012 BRN Symposium February 23, 2012 NHGRI: Jeff Struewing, Simona Volpi and Cathy Ng NIMH: Susan Koester and Roger Little Genotype-Tissue Expression (GTEx) NIH Common Fund (commonfund.nih.gov/gtex) Co-chairs – Eric Green, NHGRI & Tom Insel, NIMH Lead ...
This is a normalized dataset from the original RNAseq dataset downloaded from Genotype-Tissue Expression (GTEx) project: www.gtexportal.org: RNA-SeQCv1.1.8 gene rpkm Pilot V3 patch1.The data was used to analyze how tissue samples are related to each other in terms of gene expression data ...
In this study, 1573 differentially expressed genes, related to chronological age, from the Genotype-Tissue Expression (GTEx) project, were categorized as upregulated age-associated genes (UAGs) and downregulated age-associated genes (DAGs). Characteristics in evolution, expression, function and ...
Farm animal Genotype-Tissue Expression (FarmGTEx) 项目致力于通过全球科学家的合作,为家养动物构建一个全面的分子表型QTL数据库,从而帮助我们更好地解析重要经济性状以及环境适应性的分子遗传机制,同时促进新的育种手段(比如基因编辑)和比较基因组学的发展。