Here, we review mutations that have been identified in genes involved in autophagy and their associations with neurodegenerative diseases.doi:10.1038/s41421-020-0185-8Eleanna StamatakouLidia WrobelSandra Malmgren HillClaudia PuriDavid Chaim Rubinsztein...
Expression Changes of Genes Involved in Autophagy of the Endoplasmic Reticulum Network in Animal Models of Alzheimer's Disease 来自 Semantic Scholar 喜欢 0 阅读量: 8 作者:Z Gharib,N Sanchooli,N Sanadgol 摘要: Background and Aim This study aimed to investigate the association between Endoplasmic ...
Among them, insulin/IGF and TOR signaling pathway, MAP kinase and JNK signaling pathway, and ecdysone signaling are known to be involved in autophagy. Together with the identification of autophagy genes, the results of our screen suggest that autophagy counteracts Dcp-1-induced apoptosis. Consistent...
The expression levels of genes that interact with the SARS-CoV-2 virus or are involved in the subsequent host response are hypothesized to be an important host factor that could partially underlie the substantial inter-individual variability in COVID-19 susceptibility and progression [9,10,11]. T...
There is provided compositions and methods for improving the therapeutic efficacy of various cancer treatments, for example endocrine therapy, chemotherapy or radiation therapy, by inhibiting the expression of one or more genes involved in the cellular autophagy response. The compositions include ...
a gene involved in autophagy47. At this locus, the derived allele T is positively associated with the expression ofBECN1in the blood and negatively with the lifespan (−0.33 year per allele,PGWAS = 3.58 × 10−8). In the blood, an increase of 1 SD in genetically determ...
In its classical form, autophagy is a pathway by which cytoplasmic constituents, including intracellular pathogens, are sequestered in a double-membrane-bound autophagosome and delivered to the lysosome for degradation. This pathway has been linked to diverse aspects of innate and adaptive immunity, inc...
Autophagy is induced during cell death by incompatibility and is essential for differentiation in the filamentous fungus Podospora anserina SummaryIn filamentous fungi, a cell death reaction occurs when cells of unlike genotype fuse. This cell death reaction, known as incompatibility reaction, ... B ...
Furthermore, the functional enrichment analysis for the cluster using Metascape and HiPlot showed that the hub genes were mainly involved in autophagy, phosphatidylinositol kinase activity, Kaposi sarcoma-associated herpesvirus infection and Thyroid stimulating hormone (TSH) signaling pathway (Fig. 4D,E)....
Autophagy appears to play an important role in trypanosomatid differentiation, and several lines of evidence indicate that it is then also involved in the ... Michels PAM,F Bringaud,M Herman,... - 《Biochimica Et Biophysica Acta Molecular Cell Research》 被引量: 102发表: 2006年 加载更多来源...