These molecules have been named ATG genes (AuTophaGy related genes). The screening for new key molecules involved in autophagy has greatly promoted the characterization of the mechanism of the autophagy machinery and provides multiple targets for the development of autophagy-based regulatory drugs....
Here, we review mutations that have been identified in genes involved in autophagy and their associations with neurodegenerative diseases.doi:10.1038/s41421-020-0185-8Eleanna StamatakouLidia WrobelSandra Malmgren HillClaudia PuriDavid Chaim Rubinsztein...
Autophagy has been known as type II programmed cell death that can be activated by irradiation, especially when apoptosis is blocked, but the underlying molecular mechanism is largely unknown. We demonstrated that proapoptotic genes PUMA and Bid are involved in the regulation of autophagic cell ...
Among them, insulin/IGF and TOR signaling pathway, MAP kinase and JNK signaling pathway, and ecdysone signaling are known to be involved in autophagy. Together with the identification of autophagy genes, the results of our screen suggest that autophagy counteracts Dcp-1-induced apoptosis. Consistent...
There is provided compositions and methods for improving the therapeutic efficacy of various cancer treatments, for example endocrine therapy, chemotherapy or radiation therapy, by inhibiting the expression of one or more genes involved in the cellular autophagy response. The compositions include ...
[28, 32]; host genes with protein-protein interactions with viral proteins [29]; differentially expressed genes as a response to the infection in cultured airway epithelial cells [30]; genes involved in autophagy that might counteract viral infection [31]; and other high interest genes from the...
Autophagy is a highly conserved process in eukaryotes that is used to recycle the cellular components from the cytoplasm. It plays a crucial function in responding to both biotic and abiotic stress, as well as in the growth and development of plants. Autophagy-related genes (ATG) and their fun...
A still increasing number of reports, however, has revealed that numerous diseases are caused or appear to be caused by mutations in ATG genes and other genes involved in autophagy. This review focuses on these pathologies with the goal of giving a complete overview of congenital defects that ...
Polymorphisms associated with two genes in the autophagy pathway, ATG16L1 and IRGM1, have been implicated in susceptibility to Crohn’s disease, an idiopathic inflammatory disease typically involving the gastrointestinal tract. The intestinal mucosa is a
Comprehensive analysis of autophagy status and its relationship with immunity and inflammation in ischemic stroke through integrated transcriptomic and single-cell sequencing Xiaole Zhu Zhongman Zhang Xufeng Chen Article18 Jan 2025 Lipid metabolism-related genes are involved in the formation of macrophag...