Autophagy-related proteins are functionally active in human spermatozoa and may be involved in the regulation of cell survival and motility. Sci Rep. 2016; 6 :33647.Aparicio, I. M. et al. Autophagy-related proteins are functionally active in human spermatozoa and may be involved in the ...
Fujita, N. et al. Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitin.J. Cell Biol.203, 115–128 (2013).Study demonstrating that ubiquitination is required for the recruitment of autophagy-related proteins to ruptured endosomes, and clarifying the mechanism...
Final formation of mature autophagosome includes nucleation of the multiple Atg proteins at PAS, elongation of the isolation membrane, and maturation of autophagosome, and four functional units are involved in these processes (Fig.1b). The multiple Atg proteins gathering onto the PAS lead to the f...
Immune thrombocytopenia (ITP) is a common autoimmune disorder, and the complex dysregulation of cellular immunity has been observed; however, the relationship between autophagy‐related proteins and immune responses in ITP remains unclear. Using real‐time quantitative polymerase chain reaction (RT㏄CR),...
The discovery of autophagy-related ('ATG') proteins in the 1990s greatly advanced the mechanistic understanding of autophagy and clarified the fact that autophagy serves important roles in various biological processes. In addition, studies have revealed other roles for the autophagic machinery beyond ...
Autophagy, as a type II programmed cell death, plays crucial roles with autophagy-related (ATG) proteins in cancer. Up to now, the dual role of autophagy both in cancer progression and inhibition remains controversial, in which the numerous ATG proteins and their core complexes including ULK1/2...
The autophagosome arises from the phagophore (or isolation membrane), which expands and closes, engulfing cytosolic cargo in a process that requires the concerted action of several autophagy-related proteins (ATG) [33]. From: Pharmacological Research, 2016 ...
Individual autophagy proteins additionally modulate expression of MHC class I molecules for CD8+T cell activation. The emergence and expansion of autoreactive CD4+and CD8+T cells are considered to play a key role in the pathogenesis of multiple sclerosis (MS) and its animal model experimental ...
Autophagy is an intracellular bulk degradation system that is highly conserved in eukaryotes. The discovery of autophagy-related ('ATG') proteins in the 1990s greatly advanced the mechanistic understanding of autophagy and clarified the fact that autophagy serves important roles in various biological proc...
China* qzliu@whu.edu.cnAbstractAutophagy is a conserved cellular process playing a role in maintenance of cellular homeo-stasis and response to changing nutrient conditions via degradation and recirculation of cel-lular redundant components. Autophagy-related proteins (Atg) play important function inauto...