The discovery of autophagy-related ('ATG') proteins in the 1990s greatly advanced the mechanistic understanding of autophagy and clarified the fact that autophagy serves important roles in various biological processes. In addition, studies have revealed other roles for the autophagic machinery beyond ...
The ATG proteins Autophagy-related (ATG) proteins are essential for the formation of autophagosomes, a critical hallmark of the autophagy pathway. The process of autophagosome formation proceeds through the steps of initiation, nucleation, elongation, closure, and ultimately fusion, each of which is ...
The autophagosome arises from the phagophore (or isolation membrane), which expands and closes, engulfing cytosolic cargo in a process that requires the concerted action of several autophagy-related proteins (ATG) [33]. From: Pharmacological Research, 2016 ...
Autophagy-related proteins measured in umbilical blood cord samples from human newborns: what can we learn from?doi:10.1038/s41390-024-03382-2Vanessa GinetJulien PuyalAnita C. TruttmannNature Publishing Group USPediatric Research
Autophagy is an intracellular bulk degradation system that is highly conserved in eukaryotes. The discovery of autophagy-related ('ATG') proteins in the 1990s greatly advanced the mechanistic understanding of autophagy and clarified the fact that autophagy serves important roles in various biological proc...
These ATG proteins and related PPIs govern autophagy pathways in an intricate and controlled manner. A few protein complexes formed by critical PPIs are well described in literature41, 42, 43, 44, 45: (1) The ULK1 complex (or called ATG1 complex in yeast)46. This complex consists of four...
athe expression of autophagy-related and apoptosis-related genes and proteins 与autophagy相关和与apoptosis相关的基因和蛋白质表示[translate]
Beyond self-eating: the control of nonautophagic functions and signaling pathways by autophagy-related proteins. J. Cell Biol. 217, 813–822 (2018). Article CAS PubMed PubMed Central Google Scholar Al-Younes, H. M. et al. Autophagy-independent function of MAP-LC3 during intracellular ...
The first genetic screening of autophagy was conducted in Ohsumi’s laboratory, which analyzed this process in yeast and identified 15 autophagy-related proteins (ATGs)4. So far, over 30 ATGs have been identified5. The autophagy pathway is frequently divided into various individual stages: ...
We found that MoHat1, a histone acetyltransferase (HAT) homolog, had a role in the regulation of autophagy through the acetylation of autophagy related proteins MoAtg3 and MoAtg9. We also found that MoHat1 was subject to regulation by the protein kinase MoGsk1 that modulated the translocation...