The discovery of autophagy-related ('ATG') proteins in the 1990s greatly advanced the mechanistic understanding of autophagy and clarified the fact that autophagy serves important roles in various biological processes. In addition, studies have revealed other roles for the autophagic machinery beyond ...
but also to the greater susceptibility of preterm infants later in life. Further research is needed to clarify the significance of these gestational changes in autophagy-related proteins in blood cord plasma. To gain further insight into the correlation...
The ATG proteins Autophagy-related (ATG) proteins are essential for the formation of autophagosomes, a critical hallmark of the autophagy pathway. The process of autophagosome formation proceeds through the steps of initiation, nucleation, elongation, closure, and ultimately fusion, each of which is ...
Till now, over 30 AuTophaGy-related (Atg) genes have been identified in yeast Saccharomyces cerevisiae, and their homologs were characterized in higher eukaryotes. These ATG proteins are hierarchically recruited to the autophagosome formation site for the boosting of the core autophagic machinery, which...
Autophagy-related proteins measured in umbilical blood cord samples from human newborns: what can we learn from?doi:10.1038/s41390-024-03382-2Vanessa GinetDepartment of Women, Mother and ChildClinic of Neonatology, University Hospital Center of Vaud Lausanne SwitzerlandJulien Puyal...
Autophagy is an intracellular bulk degradation system that is highly conserved in eukaryotes. The discovery of autophagy-related ('ATG') proteins in the 1990s greatly advanced the mechanistic understanding of autophagy and clarified the fact that autophagy serves important roles in various biological proc...
These ATG proteins and related PPIs govern autophagy pathways in an intricate and controlled manner. A few protein complexes formed by critical PPIs are well described in literature41, 42, 43, 44, 45: (1) The ULK1 complex (or called ATG1 complex in yeast)46. This complex consists of four...
athe expression of autophagy-related and apoptosis-related genes and proteins 与autophagy相关和与apoptosis相关的基因和蛋白质表示[translate]
The expression levels of three autophagy-related proteins, namely light chain 3 (LC3), Beclin 1 and p62, were analyzed by immunohistochemistry using samples from 510 patients with primary gastric cancer. LC3, Beclin 1, and p62 expression was positive in 79 (15.5%), 126 (24.7%) and 251 (...
The roles of autophagy-related proteins as diagnostic or monitoring biomarkers in Parkinson’s disease (PD) have not been clearly elucidated. We recruited 32 patients with early-stage PD and 28 control subjects, and evaluated parkinsonian motor symptoms