The discovery of autophagy-related ('ATG') proteins in the 1990s greatly advanced the mechanistic understanding of autophagy and clarified the fact that autophagy serves important roles in various biological processes. In addition, studies have revealed other roles for the autophagic machinery beyond ...
Autophagy, as a type II programmed cell death, plays crucial roles with autophagy-related (ATG) proteins in cancer. Up to now, the dual role of autophagy both in cancer progression and inhibition remains controversial, in which the numerous ATG proteins and their core complexes including ULK1/2...
This cellular process is mediated by autophagy-related (Atg) proteins, which govern cargo recognition and formation of a nascent organelle called the autophagosome. Several Atg proteins have been identified, including Atg3 and the Atg12-Atg5-Atg16L1 complex. Recently, connections between autophagy and...
Autophagy is an intracellular bulk degradation system that is highly conserved in eukaryotes. The discovery of autophagy-related ('ATG') proteins in the 1990s greatly advanced the mechanistic understanding of autophagy and clarified the fact that autophagy serves important roles in various biological proc...
The ATG proteins Autophagy-related (ATG) proteins are essential for the formation of autophagosomes, a critical hallmark of the autophagy pathway. The process of autophagosome formation proceeds through the steps of initiation, nucleation, elongation, closure, and ultimately fusion, each of which is ...
ATG proteins The AuTophaGy-related (ATG) proteins are the key players regulating and mediating macroautophagy. On a note, there are also genes essential for the progression of autophagy that are not called ATG. They are vesicles with a double lipid bilayer, which are formed during macr...
1. Li, Xiaohua; He, Shikun; Ma, Binyun (2020). Autophagy and autophagy-related proteins in cancer. Molecular Cancer, 19(1), 12–. 2. Yorimitsu, T; Klionsky, D J (2005). Autophagy: molecular machinery for self-eating. , 12(0), 1542–1552. ...
These ATG proteins and related PPIs govern autophagy pathways in an intricate and controlled manner. A few protein complexes formed by critical PPIs are well described in literature41, 42, 43, 44, 45: (1) The ULK1 complex (or called ATG1 complex in yeast)46. This complex consists of four...
Autophagy is an intracellular bulk degradation system that is highly conserved in eukaryotes. The discovery of autophagy-related ('ATG') proteins in the 1990s greatly advanced the mechanistic understanding of autophagy and clarified the fact that autophagy serves important roles in various biological proc...
Autophagy-related (Atg) proteins are eukaryotic factors participating in various stages of the autophagic process. Thus far 34 Atgs have been identified in yeast, including the key autophagic protein Atg8. The Atg8 gene family encodes ubiquitin-like prot