However, few studies exist about the single nucleotide polymorphisms (SNPs) in MAP1LC3A, MAP1LC3B, ATG4A, ATG4B, ATG4C, ATG7, and ATG13, which belong to the autophagy-related genes concerning AG. This study aimed to detect biomarkers associated with AG. Herein, H. pylori-positive s...
Autophagy-related genes (ATG) and their functions have been identified in numerous crop species. However, their specific tasks in potatoes (Solanum tuberosum L.), are still not well understood. This work is the first to identify and characterize the potato StATG18 subfamily gene at the whole-...
AFold-enrichment of significantly changed pathways (p < 0.05) between H2O2-treated ATG7 KOvsH2O2-treated WT HLE-B3 cells based on KEGG (Kyoto Encyclopedia of Genes and Genomes)-enrichment analysis. (red, up-regulated pathways; blue, down-regulated pathways).BHeatmap of differentially express...
Then the RT-PCR technique was employed to evaluate the expressions ofp62/SQSTM, autophagy-related genes(ATG)5,ATG12,ATG16L1,ATG10, as well asGAPDHandLC3. By injecting apomorphine, the striatal lesion group showed a significant contralateral rotation at fourth week as compared to the baseline. ...
Till now, over 30 AuTophaGy-related (Atg) genes have been identified in yeast Saccharomyces cerevisiae, and their homologs were characterized in higher eukaryotes. These ATG proteins are hierarchically recruited to the autophagosome formation site for the boosting of the core autophagic machinery, which...
The implications of autophagy-related genes in serious neural degenerative diseases have been well documented. However, the functions and regulation of the family genes in embryonic development remain to be rigorously studied. Here, we report on for the first time the important role of atg5 gene in...
Nakagawa, I. et al. Autophagy defends cells against invading group AStreptococcus.Science306, 1037–1040 (2004).Study clarifying, through the use of and LC3 and cells deficient in genes encoding ATG proteins, the fact that autophagy can target intracellular bacteria. ...
Study clarifying, through the use of and LC3 and cells deficient in genes encoding ATG proteins, the fact that autophagy can target intracellular bacteria. Article CAS PubMed Google Scholar Gutierrez, M.G. et al. Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis ...
Although autophagic structures by electron microscopy examination were firstly reported by Christian de Duve under 60 years ago, the molecular mechanism of autophagy regulation remained mostly unknown until discovery of yeast Atg genes in the 1990s, which greatly promoted the mechanistic understanding of ...
Effects of starvation stress on the expression of autophagy-related genes (ATGs) and amino acid catabolism-related genes in cowpea [Vigna unguiculata (L.) Walp] were examined by Reverse transcription-polymerase chain reaction (RT-PCR) and anti-ATG8i specific antibody. Sucrose starvation stress ...