However, few studies exist about the single nucleotide polymorphisms (SNPs) in MAP1LC3A, MAP1LC3B, ATG4A, ATG4B, ATG4C, ATG7, and ATG13, which belong to the autophagy-related genes concerning AG. This study aimed to detect biomarkers associated with AG. Herein, H. pylori-positive s...
Autophagy-related genes (ATG) and their functions have been identified in numerous crop species. However, their specific tasks in potatoes (Solanum tuberosum L.), are still not well understood. This work is the first to identify and characterize the potato StATG18 subfamily gene at the whole-...
such as the autophagy-related genes (ATGs), are involved in coordinating the various phases of autophagy [3]. Furthermore, a number of signaling pathways, including the mTOR pathway, are essential for controlling autophagy in response to intracellular cues [7]. It is very desirable to comprehen...
Validation of the ATG-based prognostic signature in an external dataset. (A) Risk plot of the external dataset. The data are presented from top to bottom for the risk score distribution, survival status of each patient and expression heatmap of the signature genes in the low-risk group and ...
Although autophagic structures by electron microscopy examination were firstly reported by Christian de Duve under 60 years ago, the molecular mechanism of autophagy regulation remained mostly unknown until discovery of yeast Atg genes in the 1990s, which greatly promoted the mechanistic understanding of ...
Then the RT-PCR technique was employed to evaluate the expressions ofp62/SQSTM, autophagy-related genes(ATG)5,ATG12,ATG16L1,ATG10, as well asGAPDHandLC3. By injecting apomorphine, the striatal lesion group showed a significant contralateral rotation at fourth week as compared to the baseline. ...
(Fig. S3D–F). Moreover, ablation of different autophagy-related genes (ATG) via the CRISPR/Cas9 system was used to rule out the non-autophagic function of ATG proteins (Fig. S3G). Both ATG7 and ATG3 knockout (KO) in HLE-B3 cells obviously delayed the oxidative stress-induced ...
The implications of autophagy-related genes in serious neural degenerative diseases have been well documented. However, the functions and regulation of the family genes in embryonic development remain to be rigorously studied. Here, we report on for the first time the important role of atg5 gene in...
Study clarifying, through the use of and LC3 and cells deficient in genes encoding ATG proteins, the fact that autophagy can target intracellular bacteria. Article CAS PubMed Google Scholar Gutierrez, M.G. et al. Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis ...
Although autophagic structures by electron microscopy examination were firstly reported by Christian de Duve under 60 years ago, the molecular mechanism of autophagy regulation remained mostly unknown until discovery of yeast Atg genes in the 1990s, which greatly promoted the mechanistic understanding of ...