Atg8 proteins undergo a unique ubiquitin-like conjugation to phosphatidylethanolamine on the autophagic membrane, a process essential for autophagosome formation. Whereas yeast has a single Atg8 gene, many other eukaryotes contain multiple Atg8 orthologs. Atg8 genes of multicellular animals can be ...
一方面,在正常条件下,mTOR高磷酸化Atg13抑制其活性。而mTOR的抑制信号,导致Atg13去磷酸化,形成ULK1(Atg1)-Atg13-FIP200复合物。 另一方面,抗凋亡蛋白Bcl-2/Bcl-XL/Bcl-w通过它们的BH3结合凹槽与Beclin 1的BH3结构域相互作用抑制其活性。而JNK1/DAPK途径能阻断这种抑制作用,具体地,JNK1磷酸化Bcl-2,DAPK磷酸...
The discovery of autophagy-related ('ATG') proteins in the 1990s greatly advanced the mechanistic understanding of autophagy and clarified the fact that autophagy serves important roles in various biological processes. In addition, studies have revealed other roles for the autophagic machinery beyond ...
Autophagy-related (Atg) proteins are eukaryotic factors participating in various stages of the autophagic process. Thus far 34 Atgs have been identified in yeast, including the key autophagic protein Atg8. The Atg8 gene family encodes ubiquitin-like proteins that share a similar structure consisting...
Autophagy, as a type II programmed cell death, plays crucial roles with autophagy-related (ATG) proteins in cancer. Up to now, the dual role of autophagy both in cancer progression and inhibition remains controversial, in which the numerous ATG proteins and their core complexes including ULK1/2...
which hinders the production of the ATG5-ATG12 conjugate that is required for autophagosome formation. Furthermore, it has been discovered that GAS5 controls autophagy via interacting with certain miRNAs that control autophagy. As an example, it has been demonstrated that GAS5 snoops on miR-23a,...
中文名称:ATG8 |自噬相关蛋白英文名称:ATG8|Autophagy-related protein 产品类别:抗体 一抗 中文名称 ATG8 |自噬相关蛋白 英文名字 供应商 Agrisera 产品货号 AS14-2769 产品报价 ￥4905.6/50ul 产品说明书 点击查看 购买方式 银行转账、电汇、支票、现金,在线支付宝及网银支付,或直接与我们电话联系400-6800-868。
The discovery of autophagy-related ('ATG') proteins in the 1990s greatly advanced the mechanistic understanding of autophagy and clarified the fact that autophagy serves important roles in various biological processes. In addition, studies have revealed other roles for the autophagic machinery beyond ...
ATG8 | Autophagy-related protein 供应商 Agrisera 产品货号 AS14-2769 产品报价 ￥询价/50ul 产品说明书 点击查看 购买方式 银行转账、电汇、支票、现金,在线支付宝及网银支付,或直接与我们电话联系400-6800-868。 产品新闻 背景资料 ATG8 (Autophagy-related protein 8) is involved in degradation and recycling...
KLH-conjugated peptide derived from Arabidopsis thaliana ATG9 protein sequence, N-terminal part, UniProt: Q8RUS5, TAIR: AT2G31260 来源宿主 兔 反应性 拟南芥 保存建议 Store lyophilized/reconstituted at -20 其他 Agrisera公司提供1000种用于植物和藻类细胞生物学研究的一抗,2000多种二抗。Agrisera公司提供的...