Macroautophagy and microautophagy are highly conserved eukaryotic cellular processes that degrade cytoplasmic material in lysosomes. Both pathways involve characteristic membrane dynamics regulated by autophagy-related proteins and other molecules, some
Mizushima N (2018) A brief history of autophagy from cell biology to physiology and disease. Nat Cell Biol 20(5):521-527.Mizushima, N. A brief history of autophagy from cell biology to physiology and disease. Nat. Cell Biol. 2018, 20, 521-527. [CrossRef] [PubMed]...
From above description, we could clearly know that alternative autophagy has been demonstrated to involve in different disease and biology process. The alternative autophagy seemed to be induced only in conditions of cellular stress rather than basal conditions. However, the formation mechanisms and biol...
From the Department of Biochemistry and Molecular Biology, Graduate School and Faculty of Medicine, University of Tokyo, Tokyo (N.M.); and the Center for Autophagy Research, Department of Internal Medicine and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas (...
2). Although autophagy is mainly regulated at the post-translational level, stress can also increase the expression of autophagy genes (Feng et al., 2015). One of the main regulators of these genes is transcription factor EB (TFEB). In resting conditions, TFEB is retained in the cytoplasm,...
the key factors in Crohn’s disease susceptibility. This chapter reviews the recent literature on the roles ofATG16L1andIRGM1in the autophagy pathway, inflammation, antimicrobial immunity, and the biology of the intestine, and discusses how these genes may contribute to Crohn’s disease pathogenesis...
Mutations and monoallelic deletions have been demonstrated in autophagy-related genes correlating with cancer promotion. Another pathway through which autophagy suppresses tumorigenesis is cell cycle. On the other hand, under hypoxia and starvation condition, tumors use angiogenesis to provide nutrients. ...
Furthermore, autophagy can be regulated by targeting genes using technologies such as small interfering RNA (siRNA), short-hairpin RNA (shRNA) and CRISPR/Cas9 system [45], [46], [47]. However, there are biological barriers in cancer cells that pose a direct challenge in treatment, requiring...
Transcriptional control of human p53-regulated genes. Nat. Rev. Mol. Cell Biol. 9, 402–412 (2008). Article CAS PubMed Google Scholar Maiuri, M. C. et al. BH3-only proteins and BH3 mimetics induce autophagy by competitively disrupting the interaction between Beclin 1 and Bcl-2/Bcl-XL...
Autophagy genes in biology and disease Article 12 January 2023 Emerging role of the Hippo pathway in autophagy Article Open access 20 October 2020 A conserved MTMR lipid phosphatase increasingly suppresses autophagy in brain neurons during aging Article Open access 17 December 2022 References de...