Concomitantly, mutations in autophagy genes have been linked to human disorders, particularly neurodegenerative diseases, emphasizing the potential pathogenic implications of autophagy defects. Accumulating genome data have also illuminated the evolution of autophagy genes within eukaryotes as well as their ...
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The series Editors invite you to submit to this article collection entitled “Autophagy Biology: Autophagy and the Cellular Mechanism of Diseases”. The series will be published in Cell & Bioscience. Autophagy is the natural cellular process of construction and destruction mechanisms involved in physiol...
mechanisms and regulationAn insight review of autophagy biology and neurodegenerative diseasesAutophagy is an intracellular catabolic system in which cytoplasmic proteins or organelles are translocated into lysosomes for degradation.Three different types of autophagy have been identified as macroautophagy,micro...
(Tsukada and Ohsumi, 1993), the role of autophagy in various human disease states was unclear, and only in the past decade has the connection between autophagy and human disease become the subject of intense study. To date, autophagy has been linked to a growing list of diseases, and it ...
Understanding the precise interplay between autophagy and the risk of age-related pathologies across organisms will eventually facilitate the development of clinical applications that promote long-term health. 展开 关键词: Biological Sciences Biochemistry and Cell Biology ...
108 The functional analysis of these genes has implicated disruptions in lysosomal biology, mitochondrial homeostasis, autophagy, vesicular trafficking, and protein aggregation. While none of the canonical autophagy genes are associated with familial PD, both genetic evidence and post-mortem studies have ...
From above description, we could clearly know that alternative autophagy has been demonstrated to involve in different disease and biology process. The alternative autophagy seemed to be induced only in conditions of cellular stress rather than basal conditions. However, the formation mechanisms and biol...
(N.M.); and the Center for Autophagy Research, Department of Internal Medicine and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas (B.L.). Address reprint requests to Dr. Mizushima at the Department of Biochemistry and Molecular Biology, Graduate School of...
Autophagy is a process in which intracellular components and dysfunctional organelles are delivered to the lysosome for degradation and recycling. Autophagy has various connections to a large number of human diseases, as its functions are essential for c