Atg8 proteinAutophagyEncystationNaegleria gruberiRapamycinMembers of the Naegleria genus are free-living amoebae, and the only pathogenic specie described to date for humans is N. fowleri. However, as the complete genome of this specie has not been reported, non-pathogenic N. gruberi is ...
Autophagy-related (Atg) proteins are eukaryotic factors participating in various stages of the autophagic process. Thus far 34 Atgs have been identified in yeast, including the key autophagic protein Atg8. The Atg8 gene family encodes ubiquitin-like prot
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Atg8, a ubiquitin-like protein required for autophagosome formation, mediates membrane tethering and hemifusion. Cell 130, 165–178 (2007). Article CAS PubMed Google Scholar Xie, Z., Nair, U. & Klionsky, D. J. Atg8 controls phagophore expansion during autophagosome formation. Mol. Biol. ...
are one of the most highly-conserved eukaryotic protein families. They undergo a ubiquitin-like conjugation to phosphatidylethanolamine on the autophagic membrane. This modification is essential for autophagosome formation. Based on their amino acid sequence homology, at least eight different Atg8 ortholog...
Over 30 autophagy-related proteins (Atg) involved in autophagy have been identified in many eukaryotes, and two ubiquitin-like conjugation systems, the Atg8–phosphatidylethanolamine (PE)4 and Atg12–Atg5 systems, are required for formation of the autophagosome (13). Although the Atg12–Atg5 ...
The Crystal Structure of Atg3, an Autophagy-related Ubiquitin Carrier Protein (E2) Enzyme that Mediates Atg8 Lipidation Atg3 is an E2-like enzyme that catalyzes the conjugation of Atg8 and phosphatidylethanolamine (PE). The Atg8-PE conjugate is essential for autophagy, which... Y Yamada,NN Su...
Core ATG proteins are classified into several functional units, such as the FIP200 complex; the class III phosphoinositide 3-kinase complex; and the ATG7-mediated, ubiquitin-like conjugation system (Fig 1). The coordinated action of functional ATG protein units induces the membrane-trafficking events...
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Autophagic degradation of the 26S proteasome is mediated by the dual ATG8/ubiquitin receptor RPN10 in Arabidopsis. Mol. Cell 58, 1053–1066 (2015). Article CAS PubMed PubMed Central Google Scholar English, L. et al. Autophagy enhances the presentation of endogenous viral antigens on MHC ...