(2003) Shear-induced cyclooxygenase-2 via a JNK2/c-Jun-dependent pathway regu- lates prostaglandin receptor expression in chondrocytic cells. J Biol Chem 278: 28388–28394. 48. Saeed AI, Sharov V, White J, Li J, Liang W, et al. (2003) TM4: a free, open- sou...
inducing changes in cell cycle, proliferation, and cell death, potentially influencing the risk of cancer development in immune cells that are sensitive to radiation [34]. In particular, radiation induces apoptosis in mature T and B lymphocytes responsible for mediating adaptive...
We previously demonstrated that Ad-mda7 radiosensitized non-small-cell lung cancer (NSCLC) cell lines by enhancing an apoptosis pathway through the activation of JNK and c-Jun. In the present study, we investigated the efficacy of intratumoral administration of Ad-mda7 combined with ionizing ...
The DAVID Functional Annotation Bioinformatics Microarray Analysis (website:https://david.ncifcrf.gov/) was used for the GO enrichment and KEGG pathway analysis. The GO enriched the genes into 3 terms: Molecular Function (MF), Biological Process (BP), and Cellular Component (CC). Aq-value<0....
JNK 1/2 Smad 2/3 1/2 Smad4 c-Jun TGIF PIAS HDAC1 CBP TFE3 VDR TCF AP-1 Smad 2/3 Smad4 FoxH1 Runx3 BMP 2/4/7 MIS P Type II Type I BMPR BMPR Smad6 Smurf1 P Smad 1/5/8 SmadP 1/5/8 Smad 1/5/8 Smad4 OAZ Smad6 Smad 1/5/8 Smad4 CBP Runx2 Hoxc8 Network ...
Thus, if one is to pursue the implementation of JNK inhibitors in combination with conventional chemotherapeutics for the treatment of FLT3-TKD associated AML, our data would suggest that a thorough investigation of the optimal timing of JNK inhibitors with or without cytarabine would be needed. In...
JNK and ERK signaling pathways in multistage mouse carcinogenesis: studies in the inhibition of signaling cascades as a means to understand their in vivo biological role. Anticancer Res. 22, 755–759 (2002). 27. Taniguchi, F. et al. Activation of mitogen-activated protein kinase pathway by ...
DNA methylation is a well-established epigenetic biomarker for many diseases. Studying the relationships among a group of genes and their methylations may help to unravel the etiology of diseases. Since CpG-islands (CGIs) play a crucial role in the regul
The c-Jun N-terminal kinases (JNKs), also called stress-activated protein kinases (SAPKs), belong to the mitogen-activated protein kinase (MAPK) gene super... J Yang,L New,J Yong,... - 《Gene》 被引量: 103发表: 1998年 加载更多来源...
Three proteins that were altered at baseline (CDKN1A/p21, CDKN1B/p27, and phospho-JNK/MAPK8) did not respond to DEX in either genotype (Figure S6G). Therefore, out of 26 stress proteins analyzed by arrays, 15 proteins were affected by either CGG repeats or by DEX treatment (see Table ...