Conventional, G-skewness, and neural network-based G-quadruplex motif mining inHelicobacter pylori.Statistically significant G-quadruplex motifs are present in the coding region of metal-binding proteins.Stable G-quadruplex motifs are present in four Nickel-transport associated genes ofH. pylori.G-...
7,8. However, it is crucial to demonstrate the bona fide formation of G4 structures within an endogenous chromatin context9,10. Herein we address this through the development of G4 ChIP–seq, an antibody-based G4 chromatin
In this study, by combining nuclear magnetic resonance (NMR), circular dichroism (CD), liquid chromatography-electrospray ionization-mass spectrometry (LC-ESI-MS), and gel electrophoresis, we report an unusual topological structure of the RNA G-quadruplex motif formed by human telomere RNA r(UAG...
G4 motif formed in non-template strand near the promoter region facilitates transcription by maintaining the transcribed strand in single-stranded form (illustrated in Fig. 1B) while on the template strand it can block the transcriptional machinery by stalling the polymerase (Fig. 1C). However, ...
G4 motif hotspots exhibited non-random enrichment in genes at two locations on the antisense strand, one in the 5′ UTR and the other at the 5′ end of the first intron. Several genic G4 motifs were shown to adopt sequence-specific and potassium-dependent G4 DNA structures invitro. The...
Formation of parallel four-stranded complexes by guanine-rich motif for meiosis. Nature 334, 364–366 (1998). ADS Google Scholar Spiegel, J., Adhikari, S. & Balasubramanian, S. The structure and function of DNA G-quadruplexes. Trends Chem. 2, 123–136 (2020). CAS PubMed Central Pub...
Deletion of a conserved G-quadruplex motif in the 5′-UTR of MECP2 gene has been associated with reduced protein product and autism, suggesting that a G-quadruplex plays a role in normal protein synthesis [11]. Formation of G-quadruplexes in this region can also inhibit translation of ...
Structural and functional characterizations of the G-quartet and i-motif elements in retinoblastoma susceptibility genes (Rb). Nucleic Acids Symp. Ser. (Oxf.) 49, 177–178 (2005). Article Google Scholar Xu, Y. & Sugiyama, H. Formation of the G-quadruplex and i-motif structures in ...
a Shown is the proportion of BMI1 ChIP-seq peaks containing a putative G-quadruplex motif according to the Quadparser algorithm and using four independent sets of parameters. Top: color gradient indicating the stringency of the Quadparser parameters. G4, G-quadruplex; 1 Gray et al. 2014 param...