RNA G-quadruplexes (rG4s) are non-canonical secondary nucleic acid structures found in the transcriptome. They play crucial roles in gene regulation by interacting with G4-binding proteins (G4BPs) in cells. rG4-G4BP complexes have been associated with human diseases, making them important ...
ReviewG-quadruplex-based aptamers against protein targets in therapy and diagnostics☆ Author links open overlay panelChiara Platella a, Claudia Riccardi a, Daniela Montesarchio a, Giovanni N. Roviello b, Domenica Musumeci a bShow more Add to Mendeley Share Cite https://doi.org/10.1016/j....
Herein, a new kind of DNA nanostructure based on the coordination between calcium ions (Ca2+) and AS1411 DNA G quadruplexes to form nanoscale coordination polymers (NCPs) is developed via a simple method. Both chlorine e6 (Ce6), a photosensitizer, and hemin, an iron-containing porphyrin, ...
Hemin/G-quadruplex-based DNAzyme concatamers as electrocatalysts and biolabels for amplified electrochemical immunosensing of IgGl. Tang, J,Hou, L,Tang, D. P,Zhang, B,Zhou, J,Chen, G. N. Chemical Communications . 2012Hemin/G-quadruplex-based DNAzyme concatamers as electrocatalysts and bio...
G-quadruplex-based drug delivery carriers (GDDCs) were designed to capture and release a telomerase inhibitor in response to a target mRNA. Hybridization between a loop on the GDDC structure and the mRNA should cause the G-quadruplex structure of the GDDC to unfold and release the bound inhibit...
In this study, we present an intelligent electromagnetic-actuated microfluidic chip integrated with a G-quadruplex DNAzyme-based biocatalysis platform for rapid and sensitive tetracycline (TC) detection. In this sensing system, TC significantly quenches fluorescent magnetic carbon dots (M-CDs) via the...
In summary, a new enzyme-free and label-free fluorescent biosensor for small molecules by G-quadruplex-based HCR was developed. HCR was triggered by the released blocking probes at the present of target small molecules and numerous G-quadruplexes along DNA nanowires were self-assembled, resulting...
Molecular engineering of G-quadruplex ligands based on solvent effect of polyethylene glycolBecause various non-parallel G-quadruplexes of human telomeric sequences in K+ solution can be converted to a parallel G-quadruplex by adding polyethylene glycol (PEG) as a co-solvent, we have taken ...
In the presence of target, the hairpin struc-ture of MB would open and the region of G-quadruplex is exposed, which subsequently combines with Thiofla-vin T (ThT) to produce fluorescence. The relative fluo-rescence intensity increased as the mycotoxins concen-tration increased in a linear ...
TrondDepartmentUlvenDepartmentJohn Wiley & Sons, Ltd.Chemistry - A European JournalNielsen MC, Ulven T (2008) Selective extraction of G-quadruplex ligands from a rationally designed scaffold-based dynamic combinatorial library. Chem Eur J 14:9487–9490...