2025年2月17日,浙江大学生命科学研究院范衡宇团队(博士研究生焦宇萱为第一作者)在Science Bulletin上发表题为DHX36-mediated G-quadruplexes unwinding is essential for oocyte and early embryo development in mice的研究论文。该研究首...
A novel G-quadruplex motif modulates promoter activity of human thymidine kinase 1. Febs Journal. 2010; 277 :4254–64.Basundra R, et al. A novel G-quadruplex motif modulates promoter activity of human thymidine kinase 1. FEBS J. 2010; 277 :4254–4264. [ PubMed ]...
在几种神经退行性疾病(neurodegenerative diseases,NDs)中,这些二级结构的破坏是致病性的。 G-四链体(G-quadruplex)是由富含串联重复鸟嘌呤(G)的DNA或RNA折叠形成的高级结构。G-四分体(G-quartet)是四链体的结构单元,由Hoogsteen氢键...
a Shown is the proportion of BMI1 ChIP-seq peaks containing a putative G-quadruplex motif according to the Quadparser algorithm and using four independent sets of parameters. Top: color gradient indicating the stringency of the Quadparser parameters. G4, G-quadruplex; 1 Gray et al. 2014 param...
motif. This suggests that the canonical G4 motif is more likely to form G4 structures and induce SCE formation in vivo, or that BLM displays some specificity for G4 structures with medium-sized loops. Significant SCE enrichments were also detected at previously described “observed quadruplex ...
Formation of parallel four-stranded complexes by guanine-rich motif for meiosis. Nature 334, 364–366 (1998). ADS Google Scholar Spiegel, J., Adhikari, S. & Balasubramanian, S. The structure and function of DNA G-quadruplexes. Trends Chem. 2, 123–136 (2020). CAS PubMed Central Pub...
Several G-quartets planes, with the connection of loop nucleotides, can fold into an RNA secondary structure motif commonly referred to as the RNA G-quadruplex (rG4) (Neidle & Balasubramanian, 2006). So far, rG4s in coding and non-coding RNAs have been demonstrated to function in gene ...
3.5.2 G-quadruplex DNA and related model systems The focus of this section is on solid-state NMR studies of alkali metal ion binding to a special type of four-stranded nucleic acid structure known as the guanine-quadruplex (i.e., G-quadruplex). The basic structural motif of the G-quadrup...
该研究首次发现哺乳动物卵母细胞和早期胚胎发育过程中G-四链体(G-quadruplex, G4)结构的形成与DHX36的分布具有时空一致性,揭示了DHX36参与结合与解开DNA及pre-rRNA上的G4结构,参与调控染色质构象、基因转录和pre-rRNA剪切加工等过程,...