DNA:RNA hybrid G-quadruplexG-quadruplexes, intricate four-stranded structures composed of G-tetrads formed by four guanine bases, are prevalent in both DNA and RNA. Notably, these structures play pivotal roles in human telomeres, contributing to essential cellular functions...
promoter G-quadruplexes Matteo Scalabrin*, Ilaria Frasson*, Emanuela Ruggiero*, Rosalba Perrone, Elena Tosoni, Sara Lago, Martina Tassinari, Giorgio Palù & Sara N. Richter G-quadruplexes are four-stranded conformations of nucleic acids that act as cellular epigenetic ...
Genomics: Where the G-quadruplexes areBALASUBRAMANIAN, ShankerQUADRUPLEX nucleic acidsDNAGENOMICSGENOMESNature Methods 12, 806 (2015). doi:10.1038/nmeth.3572Author: Tal NawyA new sequencing method identifies G-quadruplexes genome wide.doi:10.1038/nmeth.3572Tal NawyNat MethodsNature Methods...
Figure 1. Role of RNA G-Quadruplexes (RG4s) in RNA Biology, Cellular Processes, and Human Diseases. RG4s can regulate any gene expression step, from transcription to protein synthesis, including pre-mRNA maturation [including 3′-end processing which results in poly-A tail addition and removal...
RNA G-quadruplexes undergo Ca2+-induced phase separation and assembly, accelerating α-synuclein sol-gel phase transition. In α-synuclein preformed fibril-treated neurons, RNA G-quadruplex assembly comprising synaptic mRNAs co-aggregates with α-synuclein upon excess cytoplasmic Ca2+ influx, eliciting...
or translation. ncRNAs interplay with proteins or other RNAs through not only classical sequence-based mechanisms but also unique higher-order structures such as RNA G-quadruplexes (rG4s). rG4s are predictably formed in guanine-rich sequences and are closely related to various human diseases, such...
G-quadruplexesquadruplex bindingtelomeretherapeutic targetSummary This chapter contains sections titled: Introduction Quadruplex Fundamentals Genomic Quadruplexes Quadruplexes in Human Telomeres Quadruplexes as Anticancer Targets – Evidence fromIn Vivo Studies Native Quadruplex Structures Quadruplex–Small-Molecule ...
G-Quadruplexes (G4s) 来自 Wiley 喜欢 0 阅读量: 64 作者: SN Richter 摘要: Guanine‐rich regions of nucleic acids can fold into G﹒uadruplex, a secondary structure formed by four strands of deoxyribonucleic acid (DNA) or ribonucleic acid (RNA). In the G﹒uadruplex, guanines bind via ...
Despite the demonstrated importance of DNA G-quadruplexes (G4s) in health and disease, technologies to readily manipulate specific G4 folding for functional analysis and therapeutic purposes are lacking. Here we employ G4-stabilizing protein/ligand in conjunction with CRISPR to selectively facilitate ...
DNA sequences containing consecutive guanines organized in 4-interspaced tandem repeats can form stable single-stranded secondary structures, called G-quadruplexes (G4). Herein, we report that the Polycomb group protein BMI1 is enriched at heterochromati